• Publications
  • Influence
Staging of Argyrophilic Grains: An Age‐Associated Tauopathy
TLDR
The study confirms that dementia with grains is an age-associated tauopathy with relatively uniform distribution and may independently contribute to cognitive decline in the elderly and propose the following staging paradigm.
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.
TLDR
Findings establish SNCA as a definite susceptibility gene for sporadic PD, a major component of Lewy bodies, the pathological hallmark of PD.
Lewy body-related alpha-synucleinopathy in aging.
TLDR
The findings indicate that LBs are associated with cognitive decline, either independently or synergistically with neurofibrillary tangles and senile plaques, and suggests a gender-specific risk factor.
Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study.
TLDR
It is found that rs11614913 and rs2910164 do not pose general cancer risk, but rs116 14913 may influence gastric cancer in Japanese elderly population.
Lewy Body Pathology Involves Cutaneous Nerves
TLDR
It is demonstrated for the first time that the skin is involved and may be a highly specific and useful biopsy site for the pathological diagnosis of LB diseases.
Accumulation of phosphorylated alpha-synuclein in aging human brain.
TLDR
The findings suggest that LB-related pathology initially involves the neuronal perikarya, dendrites, and axons, causes impairment of axonal transport and synaptic transmission, and later leads to the formation of LBs, a hallmark of functional disturbance long before neuronal cell death.
Telomere lengths are characteristic in each human individual
TLDR
Telomere lengths did not show clear correlation with tissue renewal times in vivo, but rather were characteristic for individuals.
Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations
TLDR
It is demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians, and in both Japanese and Koreans.
Incidence and Extent of Lewy Body-Related &agr;-Synucleinopathy in Aging Human Olfactory Bulb
TLDR
The results indicate a high incidence of LBAS in the aging human OB and suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease.
Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma.
TLDR
There was no evidence to support the previously held view that Barrett adenocarcinoma is nearly always accompanied and preceded by intestinal-type mucosa, and it was not proven histogenetically that the background mucosa of esophageal adenOCarcinomas is the intestinal type.
...
1
2
3
4
5
...