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Staging of Argyrophilic Grains: An Age‐Associated Tauopathy
We have reported that the ambient gyrus is the site with the greatest accumulation of argyrophilic grains (AGs) and that the degeneration of the ambient gyrus is responsible for dementia with grains.Expand
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Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.
Parkinson's disease (PD), one of the most common human neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. PD is a complexExpand
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Lewy body-related alpha-synucleinopathy in aging.
To clarify the significance of Lewy body (LB)-related alpha-synucleinopathy in aging, we investigated the incidence of LBs in 1,241 consecutive autopsy cases (663 males and 578 females). LB pathologyExpand
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Lewy Body Pathology Involves Cutaneous Nerves
Involvement of the peripheral autonomic nervous system is a core feature of Lewy body (LB) diseases, including Parkinson disease (PD), PD with dementia, and dementia with LBs. To investigate theExpand
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Accumulation of phosphorylated alpha-synuclein in aging human brain.
Alpha-synuclein in Lewy bodies (LBs) is phosphorylated at Ser129. We raised monoclonal and polyclonal antibodies to this phosphorylation site (psyn) and examined 157 serial autopsy brains from aExpand
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Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study.
BACKGROUND Single nucleotide polymorphisms (SNPs) affecting microRNA (miR) sequences may influence carcinogenesis. Our current study primarily aimed to confirm previously conducted associationExpand
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Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations
AbstractCoronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21Expand
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Telomere lengths are characteristic in each human individual
BACKGROUND A great deal of attention has been focused on telomeres in relation to cellular aging, immortality, and cancer. However, there is no simple link between telomeres and tissue turnover. WeExpand
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Reviewing the definition of “elderly”
Conventionally, “elderly” has been defined as a chronological age of 65 years old or older, while those from 65 through 74 years old are referred to as “early elderly” and those over 75 years old asExpand
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Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study.
OBJECTIVE We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to ischemic stroke. METHODS A total of 6341 individuals from threeExpand
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