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Pharmacokinetics and intrapulmonary concentrations of linezolid administered to critically ill patients with ventilator-associated pneumonia*
TLDR
This study suggests that a dosage of 600 mg administered intravenously twice daily to critically ill patients with Gram-positive ventilator-associated pneumonia would achieve success against organisms with minimum inhibitory concentrations as high as 2–4 mg/L in both plasma and epithelial lining fluid.
Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia*
TLDR
A target piperacillin serum concentration of at least 35–40 mg/L is probably required to provide alveolar concentrations exceeding the susceptibility breakpoint for Gram-negative bacteria during ventilator-associated pneumonia, suggesting that therapeutic drug monitoring should be performed in order to adjust the daily dose.
Steady-state plasma and intrapulmonary concentrations of cefepime administered in continuous infusion in critically ill patients with severe nosocomial pneumonia*
TLDR
The administration of 4 g of cefepime in continuous infusion in critically ill patients with severe nosocomial pneumonia appears to optimize the pharmacodynamic profile of this andbgr;-lactam by constantly providing concentrations in excess of minimal inhibitory concentration of most of susceptible organisms over the course of therapy in both serum and epithelial lining fluid.
Simultaneous determination of levofloxacin, gatifloxacin and moxifloxacin in serum by liquid chromatography with column switching.
TLDR
The on-line process of extraction avoids time-consuming treatment of the samples before injection and run time is shortened, and the recovery, selectivity, linearity, precision and accuracy of the method are convenient for pharmacokinetic studies or routine assays.
Quantitative and qualitative control of cytotoxic preparations by HPLC-UV in a centralized parenteral preparations unit.
TLDR
Controls of cytotoxic preparations were installed to avoid the administration of defective chemotherapies to patients and finally to use their results to identify error factors; as a result, corrective measures will be taken in order to reduce error frequency.
Plasma and lung concentrations of ceftazidime administered in continuous infusion to critically ill patients with severe nosocomial pneumonia
TLDR
The administration of 4 g ceftazidime in continuous infusion in critically ill patients with severe nosocomial pneumonia provides concentrations in excess of the minimal inhibitory concentration of many susceptible organisms over the course of therapy both in serum and ELF.
Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR Study)
TLDR
The monitoring of lopinavir/rironavir-based HAART efficacy should include the number of baseline lopinvir/ritonavir mutations, intracellular and plasma lop Scandinavianir Cmin and GIQ calculation.
Virologic response to nelfinavir-based regimens: pharmacokinetics and drug resistance mutations (VIRAPHAR study)
TLDR
The authors' data confirm the association among individual pharmacokinetic parameters, genotype pattern and virological response to NFV-containing regimens as similar in patients with or without emergence of these neo-mutations.
Pharmacokinetics and intrapulmonary diffusion of levofloxacin in critically ill patients with severe community-acquired pneumonia
TLDR
The results suggest that in critically ill patients who are receiving mechanical ventilation and have severe community-acquired pneumonia and creatinine clearance of >40 mL/min, the administration of 500 mg of intravenous levofloxacin once and twice daily allows for the exceeding of pharmacodynamic thresholds predictive of outcome.
Protonation equilibrium and lipophilicity of moxifloxacin.
TLDR
The apparent partition coefficient versus pH profile of moxifloxacin showed a parabolic curve in n-octanol/buffer system which reached near pI, and the true partition coefficient was calculated from the log P(app) and microconstants values.
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