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Oxygen free radicals and metallothionein.
TLDR
The evidence supporting induction of metallothionein synthesis by oxidative stress, possible mediators for this induction, and the radical scavenging capability of met allothioneIn in tissues and cells are reviewed.
Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of
TLDR
It is highly suggested that the decrease in the size of the ventral prostate by maternal TCDD exposure might be due to decreased responsiveness of the prostate to androgen due to an insufficient expression level of androgen receptor during puberty.
Tissue specific induction of metallothionein synthesis by tumor necrosis factor-alpha.
TLDR
Effect of tumor necrosis factor-alpha (TNF), which is supposed to be one of the mediators responsible for endotoxin, on metallothionein (MT) synthesis was determined in various tissues of rats and Antioxidative role of the MT synthesized by TNF was discussed.
Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs.
TLDR
The results suggest that AY-9944 and other cationic amphiphilic drugs may cause the reduction of acid sphingomyelinase activity by inducing an increased rate of degradation of the enzyme or by causing an irreversible inactivation via some undetected factor.
Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats.
TLDR
It is concluded that chronic ethanol consumption decreases hepatic vitamin A, and that some mechanisms other than malnutrition and malabsorption may be involved in this process.
Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6.
TLDR
It is suggested that metallothionein and Mn-SOD induced by cytokines in the liver exert an antioxidative role during acute phase response, therefore preventing tissues from injury by oxidative stress.
Rat thyroid hyperplasia induced by gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
TLDR
G gestational and lactational exposure to TCDD was found to disrupt thyroid hormone homeostasis, which results in a sustained excessive secretion of TSH, followed by the hyperplasia of thyroid follicular cells.
Hepatotoxicity of vitamin A and ethanol in the rat.
TLDR
Findings suggest that a metabolite of vitamin A rather than vitamin A itself may have been responsible for the potentiation ofitamin A toxicity by ethanol, and implications for the routine treatment of alcoholics with vitamin A and the monitoring for possible signs of toxicity are discussed.
Measurement of plasma metallothionein-I in the assessment of the zinc status of zinc-deficient and stressed rats.
TLDR
It appears that reduced plasma levels of both zinc and MT-I are indicative of a zinc deficiency state and that assay of plasma MT should be of value in the diagnosis of zinc deficiency.
Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet.
TLDR
The present results indicate that the metabolite PBQ is the reactive species for the initiation steps of bladder tumors induced by OPP-Na and OPP.
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