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Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling.
Pathological effects on mice by gambierol, possibly one of the ciguatera toxins.
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.
The divergent synthesis of molecular probes has been successfully applied to characterize the interaction of GSIs with their molecular targets and define the structural requirements for inhibitor binding to intramembrane-cleaving proteases.
The Sodium Channel of Human Excitable Cells is a Target for Gambierol
Results indicate that gambierol modulate ion fluxes by acting as a partial agonist of sodium channels in neuroblastoma cells.
Inhibition of voltage-gated potassium currents by gambierol in mouse taste cells.
Unlike other toxins involved in ciguatera, such as ciguatoxins, which affect the functioning of voltage-gated sodium channels, the preferred molecular target of gambierol is the voltage- gated potassium channel, at least in taste cells.
The Complete Structure of Maitotoxin, Part II: Configuration of the C135 ? C142 Side Chain and Absolute Configuration of the Entire Molecule
Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine*
The weaker interactions of MSVIII-19 with iGluR5 compared with dysiherbaine, together with altered stability of the interdomain interaction, may be responsible for the apparent uncoupling of domain closure and channel opening in this kainate receptor subunit.
Divergent Pharmacological Activity of Novel Marine-Derived Excitatory Amino Acids on Glutamate Receptors
- J. M. Sanders, Koichi Ito, G. Swanson
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 September 2005
The pharmacological activity and structural basis for subunit selectivity of neodysiherbaine (neoDH) and MSVIII-19 are characterized, one of which is a selective GluR5 receptor antagonist that will be of use for understanding native receptor function and designing more selective ligands for kainate receptors.
Effect of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells.
The marine dinoflagellate Gambierdiscus toxicus produces highly lipophilic, polycyclic ether toxins that cause a seafood poisoning called ciguatera. Ciguatoxins (CTXs) and gambierol represent the two…
Lantibiotic Transporter Requires Cooperative Functioning of the Peptidase Domain and the ATP Binding Domain*
- M. Nishie, M. Sasaki, J. Nagao, T. Zendo, J. Nakayama, K. Sonomoto
- Biology, ChemistryThe Journal of Biological Chemistry
- 8 February 2011
Observations suggest that the leader peptide is cleaved off inside the cells before peptide secretion; both PEP and ABD are important for NukT peptidase activity, and cooperation between these two domainsinside the cells is indispensable for proper functioning of Nuk T.