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Peripheral blood dendritic cells and monocytes are differently regulated in the elderly.
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T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV.
TLDR
Cell-mediated immunity and T-lymphocyte maturation are altered even in HIV-uninfected newborns of HIV-infected mothers; these abnormalities persist over time.
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The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
TLDR
The activation of at least two different inflammasome complexes explains AD-associated neuroinflammation and strategies targeting inflammaome activation could be useful in the therapy of AD.
View on Springer
Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease
TLDR
The association between MS disease and the MSRV-type HERV-W element now appears quite strong, as evidenced ex-vivo from serum and PBMC with post-mortem confirmation in brain lesions, and amplicon sequencing confirms the association with particular HERv-W elements.
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling…
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B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.
TLDR
B7-H1 synthesis and expression are up-regulated in HIV infection, and the degree of dysregulation correlates with the severity of disease.
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Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals
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Single-cell analysis of cytokine production shows different immune profiles in multiple sclerosis patients with active or quiescent disease
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PD1 negative and PD1 positive CD4+ T regulatory cells in mild cognitive impairment and Alzheimer's disease.
TLDR
The observation that PD1neg Treg, cells are increased in MCI patients reinforces the inflammatory origin of AD and supports a possible beneficial role of these cells inMCI that is lost in patients with full-blown AD.
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Alterations in Circulating Fatty Acid Are Associated With Gut Microbiota Dysbiosis and Inflammation in Multiple Sclerosis
TLDR
The gut microbiota dysbiosis found in MS is possibly associated with alterations of the SCFA/MCFA ratio and of the intestinal barrier; this could explain the chronic inflammation that characterizes this disease.
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