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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
- Y. Li, M. Lai, +7 authors S. Gardell
- Chemistry, MedicineProceedings of the National Academy of Sciences…
- 23 May 2000
The detergent solubilization and partial characterization of gamma-secretase suggest that gamma- secretase activity is catalyzed by a PS1-containing macromolecular complex.
Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes.
- K. M. Witherup, M. Bogusky, +4 authors M. Sardana
- Chemistry, MedicineJournal of natural products
- 1 December 1994
The peptide was found to dose-dependently increase intracellular Ca2+ at concentrations ranging from 3 to 30 microM, and this response was not blocked by a known NT antagonist.
Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.
- E. Pizzi, A. Tramontano, +5 authors R. De Francesco
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 February 1994
A model of the specificity pocket of the protease of hepatitis C virus is built on the basis of the known structures of trypsin-like serine proteases and of the conservation patterns among various hepatitis C strains to predict that the substrate of this protease should have a cysteine residue in position P1.
Deamidation of polyanion-stabilized acidic fibroblast growth factor.
- D. Volkin, A. Verticelli, +4 authors C. R. Middaugh
- Chemistry, MedicineJournal of pharmaceutical sciences
Initial deamidation events of polyanion-stabilized acidic fibroblast growth factor have no significant effect on the protein's overall conformation, thermal stability, interaction with heparin, or bioactivity, but limited aggregation of the protein was observed after prolonged storage under some conditions.
Diabetogenic potential of Alloxan in Albino Mice
Alloxan, a derivative of urea is known to be a carcinogen and cytotoxic glucose analog. It is also known to be one of the most common diabetogenic agents to assay the antidiabetic efficacy of plant…
Depolarization of Plasma Membrane Components Due To Arsenic Exposure during Spermiogenesis
Arsenic is a global threat in this century as a pollutant and it is gradually getting incorporated inside the physiological systems of plant and animals by various means. It is present in our…