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Support vector machine-based classification of Alzheimer’s disease from whole-brain anatomical MRI
PurposeWe present and evaluate a new automated method based on support vector machine (SVM) classification of whole-brain anatomical magnetic resonance imaging to discriminate between patients withExpand
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Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease.
BACKGROUND The different distribution of pathologic features in frontotemporal dementia (FTD) and Alzheimer disease (AD) predicts a predominant dysexecutive syndrome in FTD. The Frontal AssessmentExpand
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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
IMPORTANCE Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in personsExpand
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Neural correlates of cognitive impairment in posterior cortical atrophy.
With the prospect of disease-modifying drugs that will target the physiopathological process of Alzheimer's disease, it is now crucial to increase the understanding of the atypical focalExpand
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Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.
While emerging evidence suggests that neuroinflammation plays a crucial role in Alzheimer's disease, the impact of the microglia response in Alzheimer's disease remains a matter of debate. We aimedExpand
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Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
IMPORTANCE Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility isExpand
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Amnestic syndrome of the medial temporal type identifies prodromal AD
Objective: To compare the power of tests assessing different cognitive domains for the identification of prodromal Alzheimer disease (AD) among patients with mild cognitive impairment (MCI).Expand
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The amnestic syndrome of hippocampal type in Alzheimer's disease: an MRI study.
The Free and Cued Selective Reminding Test (FCSRT) is a verbal episodic memory test used to identify patients with mild Alzheimer's disease (AD). The present study investigates the relationshipsExpand
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The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers.
We describe 56 novel autosomal dominant early-onset Alzheimer disease (ADEOAD) families with PSEN1, PSEN2, and AβPP mutations or duplications, raising the total of families with mutations on knownExpand
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Memantine in behavioral variant frontotemporal dementia: negative results.
We tested the efficacy and tolerability of one-year treatment with memantine (10 mg bid) in behavioral variant frontotemporal dementia (bvFTD). BvFTD patients aged 45 to 75 years, with a Mini-MentalExpand
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