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Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.
Observations suggest that amphiregulin, a ligand of the EGFR, is involved in the acquisition of neoplastic traits in the liver and thus constitutes a novel therapeutic target in human hepatocarcinoma. Expand
The Epidermal Growth Factor Receptor: A Link Between Inflammation and Liver Cancer
The most recent evidences supporting a role for the EGFR system in inflammation-related cell signaling, with special emphasis in liver inflammation and HCC are summarized. Expand
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.
Novel insights are yielded about the mechanism by which SAM inhibits cell-cycle progression in the liver by showing that HGF and 5-aminoimidazole-4-carboxamide-riboside (AICAR), an activator of AMP-activated protein kinase (AMPK), induce the phosphorylation of AMPK in hepatocytes and that SAM blocks this process. Expand
Building essential biodiversity variables (EBVs) of species distribution and abundance at a global scale
The challenges of a ‘Big Data’ approach to building global EBV data products across taxa and spatiotemporal scales, focusing on species distribution and abundance are assessed. Expand
Novel Role for Amphiregulin in Protection from Liver Injury*
Results show that amphiregulin is a protective factor induced in response to liver damage and that it may be therapeutic in liver diseases. Expand
Comparative genomics: the evolutionary history of the Bcl-2 family.
A global phylogenetic analysis of all Bcl-2 family members is presented, showing that a clear-cut clustering into pro- and anti-apoptotic products, reproducible with different evolutionary methods, could also be obtained by analyzing restricted areas such as the BH1 and BH2 domains. Expand
Reference databases for taxonomic assignment in metagenomics
An overview of existing reference resources for both types of markers is given, highlighting strengths and possible shortcomings of their use for metagenomics purposes, and a new database of well annotated and phylogenetically classified ITS1 sequences is presented, to be used as a reference collection in metagenomic studies of environmental fungal communities. Expand
Methylthioadenosine reverses brain autoimmune disease
To assess the immunomodulatory activity of methylthioadenosine (MTA) in rodent experimental autoimmune encephalomyelitis (EAE) and in patients with multiple sclerosis.
The evolution of the adenine nucleotide translocase family.
The molecular phylogeny of ANT genes, reported in the present study, allows to date the time of divergence ofANT isoforms in various lineages and the logo analysis has been carried out to characterize the conservation features of ANt proteins particularly in their three similar domains originated by duplication. Expand
Towards global interoperability for supporting biodiversity research on essential biodiversity variables (EBVs)
GLOBIS-B (GLOBal Infrastructures for Supporting Biodiversity research), a global cooperation funded by the Horizon 2020 research and innovation framework programme, is introduced to bring together biodiversity scientists, global research infrastructure operators and legal interoperability experts to identify the research needs and infrastructure services underpinning the concept of EBVs. Expand