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Formation of antioxidants from (-)-epigallocatechin gallate in mild alkaline fluids, such as authentic intestinal juice and mouse plasma.
The oxidative dimerization of (-)-epigallocatechin gallate (EGCG), the major catechin of tea leaves (Camellia sinensis L.), in authentic intestinal juice and mouse plasma was investigated and are expected to contribute to in vivo antioxidative activities enhanced by tea drinking. Expand
Simultaneous determination of twelve tea catechins by high-performance liquid chromatography with electrochemical detection.
A high-performance liquid chromatographic method with electrochemical detection was developed for the determination of twelve tea catechins, sensitive to and appropriate for the simultaneous determination of various biologically active catechin in green tea. Expand
Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080
Matrix metalloproteinases (MMPs) play a crucial role in the process of cancer invasion and metastasis. Previous findings suggested that epigallocatechin gallate (EGCG), a main flavanol of green tea,Expand
Para-aminobenzoic acid scavenges reactive oxygen species and protects DNA against UV and free radical damage
Para-aminobenzoic acid (PABA), once considered a vitamin, is a precursor of folate for certain bacteria and is used as a sunscreen because of its UV-absorbing property. In addition to its mildExpand
Effects of long-term dietary supplement of tea polyphenols on lipid peroxide levels in rats
The results suggest that long-term dietary supplementation of TP caused the decrease of plasma TBARS, mainly due to the hypolipidemic activity and antioxidative effect of TP in vivo. Expand
Novel antiallergic catechin derivatives isolated from oolong tea.
Oral doses of C-1 and C-2 significantly inhibited type I allergic (anaphylactic) reactions in mice sensitized with ovalbumin and Freund's incomplete adjuvant and exceeded that of the major tea catechin, (-)-epigallocatechin 3-O-gallate, which has known antiallergic properties. Expand
Inhibitory effects of tea catechins and O-methylated derivatives of (-)-epigallocatechin-3-O-gallate on mouse type IV allergy.
The inhibitory effects of tea catechins, the O-methylated derivatives of (-)-epigallocatechin-3-O-gallate (EGCG), and the polyphenol extracts from tea leaves (Camellia sinensis L.) onExpand
O-Methylated Catechins from Tea Leaves Inhibit Multiple Protein Kinases in Mast Cells1
These catechins inhibit IgE/Ag-induced calcium response as well as the activation of downstream serine/threonine kinases such as Akt and c-Jun N-terminal kinase, and for the first time have revealed the molecular mechanisms of antiallergic effects of tea-derived catechINS. Expand
Antioxidants from Lespedeza homoloba. (I).
The stems of Lespedeza homoloba yielded eight new and three known phenolic compounds that had strong antioxidative activity against lipid peroxidation in the rat brain homogenate test and 3,9-Dihydroxypterocarp-6a-en and lespedezol A2 showed significant antiallergic activity in allergic (type I) mice. Expand