M. Sandigursky

Publications28
h-index15
Citations573
Highly Influential Citations22
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Thermostable uracil-DNA glycosylase from Thermotoga maritima a member of a novel class of DNA repair enzymes
Uracil-DNA glycosylase (UDG) is a ubiquitous enzyme found in eukaryotes and prokaryotes [1][2][3]. This enzyme removes uracil bases that are present in DNA as a result of either deamination of… Expand
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Uracil-DNA Glycosylase in the Extreme Thermophile Archaeoglobus fulgidus *
Uracil-DNA glycosylase (UDG) is an essential enzyme for maintaining genomic integrity. Here we describe a UDG from the extreme thermophile Archaeoglobus fulgidus. The enzyme is a member of a new… Expand
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Purification and characterization of Thermotoga maritima endonuclease IV, a thermostable apurinic/apyrimidinic endonuclease and 3'-repair diesterase.
An endonuclease IV homolog was identified as the product of a conceptual open reading frame in the genome of the hyperthermophilic bacterium Thermotoga maritima. The T. maritima endonuclease IV gene… Expand
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Escherichia coli single-stranded DNA binding protein stimulates the DNA deoxyribophosphodiesterase activity of exonuclease I.
The E. coli single-stranded binding protein (SSB) has been demonstrated in vitro to be involved in a number of replicative, DNA renaturation, and protective functions. It was shown previously that… Expand
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Multiple uracil-DNA glycosylase activities in Deinococcus radiodurans.
The extremely radiation resistant bacterium, Deinococcus radiodurans, contains a spectrum of genes that encode for multiple activities that repair DNA damage. We have cloned and expressed the product… Expand
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Heat Shock Protein 70 Binds to Human Apurinic/Apyrimidinic Endonuclease and Stimulates Endonuclease Activity at Abasic Sites*
The interaction of human heat shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrated by coimmunoprecipitation. A combination of HSP70 and HAP1 also caused a… Expand
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Protein-protein interactions between the Escherichia coli single-stranded DNA-binding protein and exonuclease I.
It was demonstrated previously that a deoxyribophosphodiesterase (dRpase) activity is associated with the DNA repair enzyme exonuclease I, and that this activity is stimulated by the addition of the… Expand
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Heat-Shock Proteins Associated with Base Excision Repair Enzymes in HeLa Cells
Abstract Mendez, F., Sandigursky, M., Franklin, W.A., Kenny, M.K., Kureekattil, R. and Bases, R. Heat-Shock Proteins Associated with Base Excision Repair Enzymes in HeLa Cells. Two enzymes of base… Expand
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Exonuclease IX of Escherichia coli.
The bacteria Escherichia coli contains several exonucleases acting on both double- and single-stranded DNA and in both a 5'-->3' and 3'-->5' direction. These enzymes are involved in replicative,… Expand
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Characterization of the full length uracil-DNA glycosylase in the extreme thermophile Thermotoga maritima.
A full length (192 amino acids) uracil-DNA glycosylase (TMUDG) has been expressed and purified from the extreme thermophile Thermotoga maritima. This protein is active up to 85 degrees C. The enzyme… Expand
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