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QuPath: Open source software for digital pathology image analysis
- P. Bankhead, M. Loughrey, +10 authors P. Hamilton
- Computer Science, Medicine
- Scientific Reports
- 4 December 2017
QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution for digital pathology and whole slide image analysis. Expand
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas and their matched… Expand
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100… Expand
Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse
- L. Li, M. Bhatia, +7 authors P. Moore
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 July 2005
Hydrogen sulfide (H2S) is synthesized in the body from l‐cysteine by several enzymes including cystathionine‐γ‐lyase (CSE). To date, there is little information about the potential role of H2S in… Expand
Derivation of Clinically Compliant MSCs from CD105+, CD24− Differentiated Human ESCs
Adult tissue‐derived mesenchymal stem cells (MSCs) have demonstrated therapeutic efficacy in treating diseases or repairing damaged tissues through mechanisms thought to be mediated by either cell… Expand
RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.
Loss of RUNX3 expression is suggested to be causally related to gastric cancer as 45% to 60% of gastric cancers do not express RUNX3 mainly due to hypermethylation of the RUNX3 promoter. Here, we… Expand
Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2)
Congenital hereditary endothelial dystrophy (CHED) is a heritable, bilateral corneal dystrophy characterized by corneal opacification and nystagmus. We describe seven different mutations in the… Expand
Contractile and Vasorelaxant Effects of Hydrogen Sulfide and Its Biosynthesis in the Human Internal Mammary Artery
- G. D. Webb, L. H. Lim, +12 authors P. Moore
- Journal of Pharmacology and Experimental…
- 1 February 2008
This study aimed to test these hypotheses: cystathionine γ-lyase (CSE) is expressed in a human artery, it generates hydrogen sulfide (H2S), and H2S relaxes a human artery. H2S is produced… Expand
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer.
A tumor suppressor function has been attributed to RUNX3, a member of the RUNX family of transcription factors. Here, we examined alterations in the expression of three members, RUNX1, RUNX2, and… Expand
CD133 expression predicts for non-response to chemotherapy in colorectal cancer
The cancer stem cell hypothesis may explain why conventional chemotherapies are unable to fully eradicate cancers. In this study, we examined both the prognostic and predictive significance of… Expand