• Publications
  • Influence
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
The viruses HIV-1, Epstein–Barr virus (EBV), cytomegalovirus (CMV) and hepatitis C virus (HCV) are characterized by the establishment of lifelong infection in the human host, where their replicationExpand
  • 1,620
  • 117
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells
In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged as an important player in the regulation of T cell responses and a promising target in vaccination strategies. However,Expand
  • 621
  • 49
Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or forExpand
  • 803
  • 41
Inhibition of dendritic cell maturation by herpes simplex virus.
Maturation of dendritic cells (DC), leading to migration and increased T cell stimulatory capacity, is essential for the initiation of immune responses. This process is triggered by a variety ofExpand
  • 398
  • 26
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.
We describe the cloning and characterization of Siglec-H, a novel murine CD33-related siglec-like molecule with 2 immunoglobulin domains. Unlike other CD33-related siglecs, Siglec-H lacksExpand
  • 231
  • 25
NKT Cells Enhance CD4+ and CD8+ T Cell Responses to Soluble Antigen In Vivo through Direct Interaction with Dendritic Cells 1
Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli or T cell help, plays a critical role in determining the quality and size of adaptive responses to Ag.Expand
  • 457
  • 17
Biology of CD1- and MR1-restricted T cells.
Over the past 15 years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids inExpand
  • 186
  • 17
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests thatExpand
  • 414
  • 16
The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells
The HIV–1 Tat protein transactivates HIV, viral and some host cell genes1. Tat can be released by infected cells2 and acts extracellularly in the microenvironment, regulating functions ofExpand
  • 386
  • 14
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads into distinctExpand
  • 207
  • 14