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Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1
Results show that CD55 and CD59 are incorporated into HIV-1 particles and function to protect virions from complement-mediated destruction, and they are the first report of host cell proteins functioning in protection of HIV- 1 from immune effector mechanisms. Expand
Effect of Stages of Maturity and Ripening Conditions on the Biochemical Characteristics of Tomato
An experiment was carried out to evaluate the biochemical characteristics of tomato in different maturity stages and ripening conditions. Tomato (Lycopersicon esculentum Mill) fruits (cv. Ruma VF)Expand
Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA*
Results imply that exosomes containing TAR RNA could directly affect the proinflammatory cytokine gene expression and may explain a possible mechanism of inflammation observed in HIV-1-infected patients under cART. Expand
Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1.
This study shows that PI of HIV bind to MBL and suggests that MBL can selectively interact with HIV in vivo via carbohydrate structures on gp120/gp41. Expand
Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein*
Exosomes derived from infected cells found to contain Tax protein and proinflammatory mediators as well as viral mRNA transcripts, including Tax, HBZ, and Env, suggest that exosomes may play an important role in extracellular delivery of functional HTLV-1 proteins and mRNA to recipient cells. Expand
CD4-Negative Cells Bind Human Immunodeficiency Virus Type 1 and Efficiently Transfer Virus to T Cells
  • Gene G. Olinger, M. Saifuddin, Gregory T. Spear
  • Biology, Medicine
  • Journal of Virology
  • 15 September 2000
Investigation of the ability of human immunodeficiency virus strain MN, a T-cell line-adapted strain of HIV, and X4 and R5 primary isolates to bind to various cell types shows that HIV binds at relatively high levels to CD4− cells and, once bound, is highly infectious for T cells. Expand
Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.
This study shows that specific alterations of the N-linked carbohydrates on HIV gp120/gp41 can enhance MBL-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL. Expand
A primary epidemic of inclusion body hepatitis in broilers.
Inclusion body hepatitis was diagnosed in 15 broiler flocks supplied by one breeder in the South Island of New Zealand and suffered mortality up to 30%, preceded by production drops associated with feed refusal and increased mortality in the breeder stock. Expand
The utilization of humanized mouse models for the study of human retroviral infections
These animal models have revolutionized the investigation of retroviral infections in vivo and marked an important advancement in the use of human CD34+ hematopoietic stem cells. Expand
U5 region of the human immunodeficiency virus type 1 long terminal repeat contains TRE-like cAMP-responsive elements that bind both AP-1 and CREB/ATF proteins.
Results indicate the DSE are TRE-like cAMP responsive elements that bind both AP-1 and CREB/ATF permitting induction of the HIV-1 LTR by both PKC and PKA activation signals. Expand