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Hospital Admission Risk Profile (HARP): Identifying Older Patients at Risk for Functional Decline Following Acute Medical Illness and Hospitalization
OBJECTIVES: To develop and validate an instrument for stratifying older patients at the time of hospital admission according to their risk of developing new disabilities in activities of daily livingExpand
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Practice guideline update summary: Mild cognitive impairment
Objective To update the 2001 American Academy of Neurology (AAN) guideline on mild cognitive impairment (MCI). Methods The guideline panel systematically reviewed MCI prevalence, prognosis, andExpand
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Magnetic Resonance Imaging Characterization of Brain Structure and Function in Mild Cognitive Impairment: A Review
Given the predicted increase in prevalence of Alzheimer's disease (AD) in the coming decades, early detection and intervention in persons with the predementia condition known as mild cognitiveExpand
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray.Expand
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Functional outcomes of acute medical illness and hospitalization in older persons.
BACKGROUND Short-stay hospitalization in older patients is frequently associated with a loss of function, which can lead to a need for postdischarge assistance and longer-term institutionalization.Expand
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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis ofExpand
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Early identification and treatment of Alzheimer's disease: Social and fiscal outcomes
Alzheimer's disease (AD) is a progressive neurodegenerative disease that places substantial burdens on those who provide support for family members with declining cognitive and functional abilities.Expand
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The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation.
First-degree family history of sporadic Alzheimer disease (AD) and the apolipoprotein E epsilon4 (APOE4) are risk factors for developing AD. Although the role of APOE4 in AD pathogenesis has beenExpand
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The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
BackgroundObesity causes or exacerbates a host of medical conditions, including cardiovascular, pulmonary, and endocrine diseases. Recently obesity in elderly women was associated with greater riskExpand
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Middle-Aged Children of Persons With Alzheimer’s Disease: APOE Genotypes and Cognitive Function in the Wisconsin Registry for Alzheimer’s Prevention
Adult children of persons with Alzheimer’s disease are at increased risk of developing Alzheimer’s disease because of hereditary, environmental, and health risk factors shared with affected parents.Expand
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