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Effect of the disease‐causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII
TLDR
Results indicate that Gly10 is required to make the protein fully active and stable, and suggests that the introduction of a bulky side chain into this position induces a local conformational change, which is unfavorable for both activity and substrate binding.
Interaction Of Platelet Activating Factor Acetyl Hydrolase (Paf Ah) Enzyme In Gln281 To Arg281 Mutation Toward Paf And Its Molecular Dynamic
TLDR
Docking result shown that amino acid residues on active site of Q281 PAF AH mutant have not recognized onPAF AH, indicating the importance effect of mutant Q281R in PAFAH recognition to its substrate.
Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X‐ray crystallographic analyses
TLDR
It is proposed that So‐RNase HI is destabilized when compared with its mesophilic and thermophilic counterparts in a localized fashion by increasing the number of amino acid residues unfavourable for protein stability.
Remarkable stabilization of a psychrotrophic RNase HI by a combination of thermostabilizing mutations identified by the suppressor mutation method.
TLDR
Results suggest that several residues are not optimal for the stability of So-RNase HI, and their replacement with other residues strikingly increases it to a level similar to that of the mesophilic counterpart.
Response of rhizobacterial communities in watermelon to infection with cucumber green mottle mosaic virus as revealed by cultivation-dependent RISA
TLDR
The cluster analysis of RISA showed that the community structure of aerobic rhizobacteria exhibited 60% similarity between healthy and infected plant, and the highest community structure similarity (50% similarity) of anaerobicRhizobacterial community structure occurred between before planting andinfected plant.
The structural insight of class III of polyhydroxyalkanoate synthase from Bacillus sp. PSA10 as revealed by in silico analysis
TLDR
The results strongly suggested that the mode of action of BacPhaCSynt obeyed the covalent catalysis mechanism.
Hibiscus Sabdariffa Linn) terhadap NF-ĸβ, TNF-α dan ICAM-1 pada Human Umbilical Vein Endothelial Cells (HUVECs) Cultured yang dipapar Low Density Lipoprotein (LDL) Teroksidasi
TLDR
Tujuan penelitian ini adalah mengetahui efek dan mekanisme kerja ekstrak teh Rosella merah terhadap aktifasi NF-κβ dan ekspresi protein TNF -α serta ICAM-1 yang menjadi mediator  inflamasi pada aterosklerosis.
Mutation of UDP-glucose binding motif residues lead to increased affinity for ADP-glucose in sugarcane sucrose phosphate synthase.
TLDR
The results showed that mutations in the R-X4-K, E-X7-E, and H-X5-V motifs significantly affect UDP-G and ADP-G binding, offering strategic insights into increasing sucrose synthesis and plant growth.
An Active of Extracellular Cellulose Degrading Enzyme from Termite Bacterial Endosimbiont
TLDR
This work aimed to characterize the extracellular cellulase from Paenibacillus spp.
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