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Xanthone derivatives: new insights in biological activities.
- M. Pinto, M. E. Sousa, M. S. Nascimento
- Chemistry, BiologyCurrent medicinal chemistry
- 30 September 2005
In this review, an array of biological/pharmacological effects is presented for both natural and synthetic xanthone derivatives, with an emphasis on some significant studies on structure-activity relationships.
Cytotoxic activity of lupane-type triterpenes from Glochidion sphaerogynum and Glochidion eriocarpum two of which induce apoptosis.
Triterpenes 2 - 7 were tested against the growth of three human tumor cell lines, MCF-7, NCI-H-460 and SF-268 and indicated that triterpenes 5 and 6 exerted their antiproliferative activity through the involvement of apoptosis while triterpene 3 did not.
Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro.
Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocyte proliferation.
Dihydroxyxanthones prenylated derivatives: synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7.
Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines.
- Cristina Gaspar Marques, M. Pedro, M. F. Simões, M. S. Nascimento, M. Pinto, B. Rodriguez
- Chemistry, BiologyPlanta medica
- 1 September 2002
Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone, and coleon U, isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative activity against five human cancer cell lines.
Effects of natural prenylated flavones in the phenotypical ER (+) MCF-7 and ER (-) MDA-MB-231 human breast cancer cells.
Prenylated xanthones: antiproliferative effects and enhancement of the growth inhibitory action of 4-hydroxytamoxifen in estrogen receptor-positive breast cancer cell line
- A. Paiva, M. E. Sousa, A. Camões, M. S. Nascimento, M. Pinto
- Biology, ChemistryMedicinal Chemistry Research
- 1 May 2012
The effects of three prenylated xanthones on the in vitro growth of estrogen-dependent ER (+) MCF-7 (breast), estrogen-independent ER (−) MDA-MB-231 cells (breast), and NCI-H460 (non-small cell lung)…
Catechols from abietic acid synthesis and evaluation as bioactive compounds.
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens.
- Cláudia Valente, M. Pedro, A. Duarte, M. S. Nascimento, P. Abreu, Maria-José U. Ferreira
- ChemistryJournal of natural products
- 23 April 2004
Diterpenes 1-3 and previously described pubescene D were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited significant antibacterial activity against Staphylococcus aureus.