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Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non‐obese diabetic (NOD) mice
Non‐obese diabetic (NOD) mice are regarded as being excellent animal models of human type 1 diabetes or insulin dependent diabetes (IDDM). This study investigated the beneficial effects of genistein
Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects.
Data suggest that naringin may play an important role in lowering plasma cholesterol and regulating the antioxidant capacity in hypercholesterolemic subjects.
Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice.
The results indicate that the UEFx can prevent insulin resistance and hepatic fat accumulation that is partly mediated by modulating the hepatic glucose and lipid homeostasis in the high fat-induced obese mice.
Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of
The inhibition of HMG-CoA reductase and ACAT activities resulting from the supplementation of either tangerine-peel extract or a combination of its bioflavonoids could account for the decrease in fecal neutral sterol that appears to compensate for the decreased cholesterol biosynthesis in the liver.
Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.
  • J. Lee, M. S. Choi, +4 authors S. Bok
  • Chemistry, Medicine
    Clinica chimica acta; international journal of…
  • 1 December 2001
Both cinnamate derivatives were potent in lipid-lowering and altering the antioxidative enzyme in rats and suggest that 3,4-di(OH)-cinnamate is more effective than 3, 4-di (OH)-hydrocinnamate in its lipid- Lowering action.
Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits.
Results would appear to indicate that naringin, a citrus bioflavonoid, plays an important role in regulating antioxidative capacities by increasing the SOD and catalase activities, up-regulating the gene expressions of SOD,Catalase, and GSH-Px, and protecting the plasma vitamin E.
The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice.
  • U. Jung, N. Baek, +9 authors M. S. Choi
  • Biology, Medicine
    Food and chemical toxicology : an international…
  • 1 October 2007
The results suggest that SBE and SSE exert an anti-diabetic effect in type 2 diabetic mice.
Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats.
  • Y. Shin, S. Bok, +5 authors Y. B. Park
  • Biology, Medicine
    International journal for vitamin and nutrition…
  • 1 September 1999
The effects of the citrus bioflavonoid naringin were tested by using it as a supplement in a high-cholesterol diet and it was found that the combination of the inhibited HMG-CoA reductase and ACAT activities could account for the decrease of fecal neutral sterols.
Anti-atherogenic property of ferulic acid in apolipoprotein E-deficient mice fed Western diet: comparison with clofibrate.
Results provide a new insight into the anti-atherogenic property of ferulic acid in the apolipoprotein E-deficient mice fed a Western diet.
Cyclooxygenase-derived products, rather than nitric oxide, are endothelium-derived relaxing factor(s) in the ventral aorta of carp (Cyprinus carpio).
Results indicate that carp aorta does not produce NO as an EDRF nor does it respond to exogenously supplied NO.