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Gastroprotection and effect of the simultaneous administration of Cuachalalate (Amphipterygium adstringens) on the pharmacokinetics and anti‐inflammatory activity of diclofenac in rats
TLDR
The experimental findings in rats suggest that CME at doses lower than 100 mg kg−1 protects the gastric mucosa from the damage induced by diclofenac sodium without altering either the anti‐inflammatory activity or the pharmacokinetics of this NSAID. Expand
Bioassay‐guided isolation of an anti‐ulcer diterpenoid from Croton reflexifolius: role of nitric oxide, prostaglandins and sulfhydryls
TLDR
Polyalthic acid, which was isolated from this plant, was the main compound with gastroprotector activity, having effectiveness similar to that found with the use of carbenoxolone. Expand
Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: role of nitric oxide, prostaglandins and sulfydryls.
TLDR
The results show that E. aschenbornianum had gastroProtective activity, that the hexane extract had the highest protective activity, and that encecanescin isolated from this extract was the main active gastroprotective agent. Expand
Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats
TLDR
Dillapiole was identified as the most active compound in this extract of P. pellucida using an ethanol-induced gastric ulcer experimental rat model and suggests that the gastroprotective mechanism of action of dillapIOle does not involve prostaglandins, NO or sulfhydryl groups. Expand
Gastroprotective activity of caryophyllene oxide: the role of nitric oxide, prostaglandins and sulfhydryls.
Article history: Received on: 14/08/2014 Revised on: 27/08/2014 Accepted on: 11/09/2014 Available online: 27/09/2014 The present study was carried out to evaluate the gastroprotective effect ofExpand
Role of Prostaglandins, Nitric oxide, Sulfhydryls and Capsaicin-sensitive Neurons in Gastroprotection of Stigmasterol and β-Sitosterol
In this investigation the gastroprotective activity of stigmasterol and β-sitosterol was evaluated. Gastric mucosal damage was induced in rats by intragastric ethanol (1 mL/rat). Rats treated orallyExpand
Gastroprotection of Suaveolol, Isolated from Hyptis suaveolens, against Ethanol-Induced Gastric Lesions in Wistar Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryls
TLDR
The results show that the hexane extract had protective activity (close to 70% when using doses between 10 and 100 mg/kg), and that the compound suaveolol, isolated from this extract, was one of the active gastroprotective agents. Expand
Mechanisms of relaxant action of a crude hexane extract of Gnaphalium liebmannii in guinea pig tracheal smooth muscle.
TLDR
The results suggest that Gnaphalium liebmannii induce relaxation of the tracheal muscle, probably via phosphodiesterase inhibition, which might explain in part their traditional use as anti-asthmatic remedy. Expand
Bioassay-Guided Isolation of an Anti-Ulcer Compound, Tagitinin C, from Tithonia diversifolia: Role of Nitric Oxide, Prostaglandins and Sulfhydryls
TLDR
The results showed that T. diversifolia had gastroprotective activity, and that the dichloromethane extract had the highest protective activity (close to 90% when using doses between 10 to 100 mg/kg), and that further the compound tagitinin C isolated from this extract was the main active gastroprot protective agent. Expand
Relaxant action mechanism of berberine identified as the active principle of Argemone ochroleuca Sweet in guinea‐pig tracheal smooth muscle
TLDR
The results suggest that the relaxant effect of berberine on tracheal muscle is due to its antagonistic effect on muscarinic acetylcholine receptors. Expand
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