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Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo
Neuronal death is a prominent, but poorly understood, pathological hallmark of prion disease. Notably, in the absence of the cellular prion protein (PrPC), the disease-associated isoform, PrPSc,Expand
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A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta.
Interleukin-1beta (IL-1beta) is overproduced in human and rodent epileptogenic tissue and it exacerbates seizures upon brain application in rodents. Moreover, pharmacological prevention of IL-1betaExpand
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Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span
Reduction of core body temperature has been proposed to contribute to the increased life span and the antiaging effects conferred by calorie restriction (CR). Validation of this hypothesis has beenExpand
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Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity.
The proinflammatory cytokine Interleukin 1 beta (IL-1beta) is elevated in obese individuals and rodents and it is implicated in impaired insulin secretion, decreased cell proliferation and apoptosisExpand
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Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons
Prion protein (PrP(C)) is a constituent of most normal mammalian cells and plays an essential role in the pathogenesis of transmissible spongiform encephalopathies (TSE). However, the normal cellularExpand
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Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
Significance Lipid transmitters, such as endocannabinoid and eicosanoids, play important roles in the nervous system and regulate behaviors that include pain, emotionality, and addiction. ChemicalExpand
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Histamine Influences Body Temperature by Acting at H1and H3 Receptors on Distinct Populations of Preoptic Neurons
The preoptic area/anterior hypothalamus, a region that contains neurons that control thermoregulation, is the main locus at which histamine affects body temperature. Here we report that histamineExpand
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Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity. Here, we show that administration of IL-18 suppresses appetite, feed efficiency, and weight regain in food-deprivedExpand
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Anandamide modulates sleep and memory in rats
In this study we have assessed the effect of the intracerebroventricular administration of anandamide (ANA) as well as its precursor metabolite arachidonic acid (AA), on the sleep-wakefulness cycle,Expand
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Interleukin‐1 System in CNS Stress
Abstract:  Proteins of the interleukin‐1 (IL‐1) system include the secreted agonist IL‐1β, and the receptor antagonist IL‐1ra, both competing for binding to the IL‐1 receptor (IL‐1R). IL‐1β andExpand
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