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A promoter-level mammalian expression atlas
TLDR
Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs in mammalian cell-type-specific promoters. Expand
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A manually curated ChIP-seq benchmark demonstrates room for improvement in current peak-finder programs
Chromatin immunoprecipitation (ChIP) followed by high throughput sequencing (ChIP-seq) is rapidly becoming the method of choice for discovering cell-specific transcription factor binding locationsExpand
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Cell-type specificity of ChIP-predicted transcription factor binding sites
BackgroundContext-dependent transcription factor (TF) binding is one reason for differences in gene expression patterns between different cellular states. Chromatin immunoprecipitation followed byExpand
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Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements
BackgroundTranscription factor binding to DNA requires both an appropriate binding element and suitably open chromatin, which together help to define regulatory elements within the genome. CurrentExpand
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Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer
TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was to identify changes in metabolism, genes and biochemical recurrence related to TMPRSS2-ERG byExpand
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A novel non-canonical Wnt signature for prostate cancer aggressiveness
Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both goodExpand
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Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration
BackgroundPRL-3 is a phosphatase implicated in oncogenesis in multiple cancers. In some cancers, notably carcinomas, PRL-3 is also associated with inferior prognosis and increased metastaticExpand
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The use of chemometrics to analyse protein patterns from gel electrophoresis
Summary Chemometrics involves strategies to analyse multivariate data using interdisciplinary approaches aiming to extract relevant information from complex data. Chemometric strategies comprise bothExpand
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Norwegian e-Infrastructure for Life Sciences (NeLS)
The Norwegian e-Infrastructure for Life Sciences (NeLS) has been developed by ELIXIR Norway to provide its users with a system enabling data storage, sharing, and analysis in a project-orientedExpand
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APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer
Docetaxel is the chemotherapeutic choice for metastatic hormone-refractory prostate cancer, however, it only marginally improves the survival rate. The purpose of the present study was to examine ifExpand
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