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Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
We have developed a high-resolution fluorescence microscopy method based on high-accuracy localization of photoswitchable fluorophores. In each imaging cycle, only a fraction of the fluorophores wereExpand
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Ordered Phosphorylation Governs Oscillation of a Three-Protein Circadian Clock
The simple circadian oscillator found in cyanobacteria can be reconstituted in vitro using three proteins—KaiA, KaiB, and KaiC. The total phosphorylation level of KaiC oscillates with a circadianExpand
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Ligands for Clathrin-Mediated Endocytosis Are Differentially Sorted into Distinct Populations of Early Endosomes
Cells rely on the correct sorting of endocytic ligands and receptors for proper function. Early endosomes have been considered as the initial sorting station where cargos for degradation separateExpand
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Visualizing infection of individual influenza viruses
Influenza is a paradigm for understanding viral infections. As an opportunistic pathogen exploiting the cellular endocytic machinery for infection, influenza is also a valuable model system forExpand
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Assembly of endocytic machinery around individual influenza viruses during viral entry
Most viruses enter cells via receptor-mediated endocytosis. However, the entry mechanisms used by many of them remain unclear. Also largely unknown is the way in which viruses are targeted toExpand
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Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells
Dengue virus (DENV) is an enveloped RNA virus that causes the most common arthropod-borne infection worldwide. The mechanism by which DENV infects the host cell remains unclear. In this work, we usedExpand
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Light-Driven Changes in Energy Metabolism Directly Entrain the Cyanobacterial Circadian Oscillator
Cyanobacterial circadian clock components are directly coupled to the metabolic status of the cell through interactions with adenine nucleotides. Circadian clocks are self-sustained biologicalExpand
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Imaging Poliovirus Entry in Live Cells
Viruses initiate infection by transferring their genetic material across a cellular membrane and into the appropriate compartment of the cell. The mechanisms by which animal viruses, especiallyExpand
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Robust and tunable circadian rhythms from differentially sensitive catalytic domains
Circadian clocks are ubiquitous biological oscillators that coordinate an organism’s behavior with the daily cycling of the external environment. To ensure synchronization with the environment, theExpand
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Endocytosis of influenza viruses.
Receptor-mediated endocytosis is known to play an important role in the entry of many viruses into host cells. However, the exact internalization mechanism has, until recently, remained poorlyExpand
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