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Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold.
TLDR
Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria
TLDR
In fungi, eubacteria, and plant chloroplasts, ring sizes of c10–c15 subunits have been observed, implying that these enzymes need 3.3–5 protons to make each ATP, but until now no higher eukaryote has been examined.
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
TLDR
A substantially enriched preparation of Alzheimer paired helical filaments has been used as a starting point for biochemical studies and sequence analysis of these peptides was used to design oligonucleotide probes for cloning a cognate cDNA, which leads to its identification as human microtubule-associated tau protein.
Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins
TLDR
The findings indicate that Grx2 plays a central role in the response of mitochondria to both redox signals and oxidative stress by facilitating the interplay between the mitochondrial glutathione pool and protein thiols.
Modulation of the Oligomerization State of the Bovine F1-ATPase Inhibitor Protein, IF1, by pH*
TLDR
The mutation of histidine 49 to lysine is predicted to abolish coiled-coil formation over residues 32–43 preventing interaction between two dimers, forcing the equilibrium toward the dimeric state, thereby freeing the N-terminal inhibitory regions and allowing them to interact with F1.
Citrin and aralar1 are Ca2+‐stimulated aspartate/glutamate transporters in mitochondria
TLDR
The results demonstrate that citrin and aralar1 are isoforms of the hitherto unidentified aspartate/glutamate carrier and explain why mutations in citrin cause type II citrullinemia in humans, and suggest a novel mechanism of Ca2+ regulation of the as partate/malate shuttle.
Arrangement of subunits in intact mammalian mitochondrial ATP synthase determined by cryo-EM
TLDR
The structure of intact bovine mitochondrial ATP synthase is presented at ∼18 Å resolution by electron cryomicroscopy of single particles in amorphous ice and the observed bend in the micelle of the detergent-solubilized complex is consistent with previous electron tomography experiments and suggests that monomers of ATP synthases are sufficient to produce curvature in lipid bilayers.
Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase.
TLDR
The Fo membrane domain of the F1Fo-ATP synthase complex has been purified from bovine heart mitochondria, providing a relatively abundant source of pure and functional Fo that is suitable for structural analysis.
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