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Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes
During enzymic Fe3+/ADP/NADPH-induced lipid peroxidation, both E2 and 2-OHE2 were found to provide good protection and underline the importance of the chemical structure of these compounds and the role of estradiol metabolism in its antioxidant effects. Expand
Antioxidant activity and polyphenol content of aqueous extracts from Colombian Amazonian plants with medicinal use.
Abstract The total phenol and flavonoid contents of 19 Amazonian plants and their related antioxidant activities were determined. The extracts from the plant leaf, bark, root, fruit and/or stem wereExpand
tert-Butyl hydroperoxide-induced lipid signaling in hepatocytes: involvement of glutathione and free radicals.
It is concluded that TBHP stimulates the release of [14C]-AA from membrane phospholipids through a PLA(2)-mediated mechanism, while endogenous GSH and ROS play a major role in this effect, while lipid peroxidation-related events are unlikely to be involved. Expand
Antioxidant activities of estrogens against aqueous and lipophilic radicals; differences between phenol and catechol estrogens.
Results indicate that the various estrogens are good scavengers of free radicals generated in both the aqueous and the lipophilic phases. Expand
Flavonoids and Other Plant Phenols in the Diet: Their Significance as Antioxidants
Phenols are universal components of plant material. Flavonoids are polyphenolic constituents of the diet with antioxidant properties by virtue of the structural arrangements and hydrogen-donatingExpand
Detection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplification refractory mutation system-PCR.
The described method provides a fast and reliable approach for determining COMT polymorphism that can be useful in large clinical studies using minimal quantity of DNA, avoiding the timely and costly use of restriction enzymes. Expand
Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles.
The Ala/Ala SOD2 genotype is a significant independent predictor of the occurrence of pregnancy in IVF and data support a role for antioxidant defense, particularly in the mitochondria, in conception in IVf. Expand
Protective effect of estrogens and catecholestrogens against peroxidative membrane damagein vitro
The present results confirm earlier findings and point toward a link between estrogen metabolism and estrogen antioxidant activity and indicate that estrogens and catecholestrogens interact with the peroxidative process at different levels with their interactions with iron or the metal-derived species being the most important modes of inhibition. Expand
Serum oxidizability and antioxidant status in patients undergoing in vitro fertilization.
The results suggest a role for ROS in the occurrence of conception in IVF and suggest a serum less protected against oxidation in women undergoing an in vitro fertilization (IVF) cycle. Expand
Pro-oxidant and antioxidant potential of catecholestrogens against ferrylmyoglobin-induced oxidative stress.
The results showed that ferrylmyoglobin induced an initial oxidative stress, mainly reflected in an early lipid peroxidation and further decrease in GSH and ATP, but cells gradually adapted to this situation, by recovering the endogenous ATP and GSH levels at longer incubation times. Expand