• Publications
  • Influence
Common variants conferring risk of schizophrenia
TLDR
Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition. Expand
Genome-wide association study identifies five new schizophrenia loci
TLDR
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. Expand
Large recurrent microdeletions associated with schizophrenia
TLDR
In a genome-wide search for CNVs associating with schizophrenia, a population-based sample was used to identify de novo CNVs by analysing 9,878 transmissions from parents to offspring and three deletions significantly associate with schizophrenia and related psychoses in the combined sample. Expand
Definition and prevalence of severe and persistent mental illness
TLDR
The three-dimensional definition selects a small group of patients with SMI who have psychotic disorders, and the two-dimensional approach allows estimates of SMI prevalence rates which include all forms of mental disorder. Expand
Disruption of the neurexin 1 gene is associated with schizophrenia.
TLDR
It is concluded that NRXN1 deletions affecting exons confer risk of schizophrenia. Expand
Patients' and relatives' satisfaction with psychiatric services: The state of the art of its measurement
  • M. Ruggeri
  • Medicine
  • Social Psychiatry and Psychiatric Epidemiology
  • 1 September 1994
TLDR
The aims of the present paper were to update work done in the field of satisfaction with mental health services in the last decade, to describe the main instruments currently available to measure patients' and relatives' satisfaction withmental health services, and to provide guidelines for the future development of instruments and their use in mental health settings. Expand
Expanding the range of ZNF804A variants conferring risk of psychosis
TLDR
As it has been proposed that variants such as rs1344706[T]—common and with low relative risk—may also serve to identify regions harboring less common, higher-risk susceptibility alleles, ZNF804A is searched for large copy number variants (CNVs) in psychosis patients and patients with other psychiatric disorders and 39 481 controls. Expand
Does Meeting Needs Improve Quality of Life?
TLDR
Higher baseline quality of life was associated with being male, a diagnosis of psychosis, higher disability, higher satisfaction with care, fewer staff-rated or patient-rated unmet needs, and fewer patients-rated met needs. Expand
Copy number variations of chromosome 16p13.1 region associated with schizophrenia
TLDR
It is concluded that duplications and perhaps also deletions of chromosome 16p13.1, previously reported to be associated with autism and MR, also confer risk of schizophrenia. Expand
Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
TLDR
An expanded set of variants in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), and two novel variants showing genome-wide significant association are found. Expand
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