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(S)‐norlaudanosoline synthase: The first enzyme in the benzylisoquinoline biosynthetic pathway
Isoquinoline alkaloids form the largest group of alkaloids in the plant kingdom. Numerous publications deal with aspects of the biosynthesis of these compounds in vivo [ 11, while isoquinolineExpand
Enzymatic formation of protopines by a microsomal cytochrome P-450 system of Corydalis vaginans
Abstract A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)- cis -N- methyltetrahydroprotoberberines has been discovered in aExpand
Partial purification and properties of S-adenosyl-l-methionine: (S)-tetrahydroprotoberberinecis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis
Abstract An enzyme has been found in different species of isoquinoline alkaloid-producing plant cell cultures which specifically N -methylates certain ( S )-tetrahydroprotoberberine alkaloids such asExpand
Benzylisoquinoline Biosynthesis by Cultivated Plant Cells and Isolated Enzymes
TLDR
It could be demonstrated that the transport of these compounds into vacuoles of Fumaria capreolata does not proceed by an ion-trap mechanism, but rather involves an active ATP-requiring, stereospecific carrier system acting only on the (S)and not on the @?)-enantiomer. Expand
Partial Purification and Properties of S-Adenosylmethionine: (R), (S)-Norlaudanosoline-6-O-Methyltransferase from Argemone platyceras Cell Cultures.
A new enzyme, S-adenosylmethionine: (R), (S)-norlaudanosoline-6-O-methyltransferase, was isolated from the soluble protein extract of A. PLATYCERAS cell cultures and purified approximately 80-fold.Expand
CANADINE SYNTHASE FROM THALICTRUM TUBEROSUM CELL CULTURES CATALYSES THE FORMATION OF THE METHYLENEDIOXY BRIDGE IN BERBERINE SYNTHESIS
TLDR
The cytochrome P-450 enzyme complex has been partly characterized from a protoberberine alkaloid producing Thalictrum tuberosum L. cell line, and has a pH optimum at pH 8.5 and a temperature optimum of 40°. Expand
Distant Precursors of Benzylisoquinoline Alkaloids and their Enzymatic Formation
The incorporation rates of labelled tyrosine, DOPA. tyramine. and dopamine have been investigated during the in vivo formation of the protoberberine alkaloid, jatrorrhizine, in callus cultures ofExpand
S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis
Suspension cultures of Berberis species are useful sources for the detection and isolation of a new enzyme which transfers the methyl group from S-adenosyl-L-methionine specifically to the 9-positionExpand
Biosynthesis of the protoberberine alkaloid jatrorrhizine
Feeding experiments with distant single or doubly labelled precursors show that the methylene dioxy group of berberine is opened in the formation of jatrorrhizine.
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