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Ubiquitin chain conformation regulates recognition and activity of interacting proteins
Conformational equilibria in ubiquitin chains provide an additional layer of regulation in the ubiquitIn system, and distinct conformations observed in differently linked polyubiquitin may contribute to the specificity of ubiquit in-interacting proteins. Expand
Carbon dots for copper detection with down and upconversion fluorescent properties as excitation sources.
Carbon dots were synthesized by a simple and green strategy for selective and sensitive Cu(2+) ion detection using both down and upconversion fluorescence to show low cytotoxicity and are applied for intracellular sensing and imaging of Cu( 2+) in biological systems. Expand
Quantum dot photoluminescence lifetime-based pH nanosensor.
The first CdSe/ZnS quantum dot photoluminescence lifetime-based pH nanosensor has been developed and has been satisfactorily applied for pH estimation in simulated intracellular media, with high sensitivity and high selectivity toward most of the intrACEllular components. Expand
Fluorescent nanoparticles for intracellular sensing: a review.
This review focuses on the developments and analytical applications of fluorescent nanoparticles in chemical and biological sensing within the intracellular environment, and points out the great potential of fluorescent NPs for fluorescence lifetime imaging microscopy (FLIM). Expand
Azamacrocycle activated quantum dot for zinc ion detection.
The results from fetal calf serum and samples mimicking physiological conditions suggested very good applicability in the determination of zinc ion in physiological samples and the versatility of the sensors was demonstrated, since different sizes (and colors) of QDs can be employed and will respond to zinc in a similar way. Expand
Fluorescence lifetime imaging microscopy for the detection of intracellular pH with quantum dot nanosensors.
It is shown that the photoluminescence (PL) lifetime of mercaptopropionic acid-capped QDs (MPA-QDs) collected from FLIM images can be used to determine intracellular pH, and the combination of FLIM methodologies with QD nanoparticles exhibits greatly improved sensitivity compared with other fluorescent dyes for pH imaging. Expand
Analytical nanosphere sensors using quantum dot-enzyme conjugates for urea and creatinine.
An enzyme-linked analytical nanosphere sensor (ANSor) is described, responding to enzyme-substrate turnover in the vicinity of a quantum dot (QD) due to coimmobilized enzyme and pH sensitive ligand.Expand
Multiplexed energy transfer mechanisms in a dual-function quantum dot for zinc and manganese.
Dual-function water-soluble core/shell-modified CdSe/ZnS quantum dot nanoparticles have been created, that exploit two different fluorescence emission pathways for the detection of two heavy metal ions: Zn(2+) and Mn(2+). Expand
Ratiometric pH-dot ANSors.
A silica based analytical nanosphere sensor (ANSor) containing quantum dots (QDs) is reported, which can measure local pH in a ratiometric fashion and is stable, robust and capable of measuring pH in the physiologically relevant range. Expand
A multi-ion particle sensor.
The first sub-micron polyacrylic sensor containing two independent ion-sensing systems is shown, that uses a single excitation wavelength and separates signals by using quantum dot donors to formExpand