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NATURAL PRODUCTS AS INDUCERS OF APOPTOSIS: IMPLICATION FOR CANCER THERAPY AND PREVENTION
Apoptosis is a programmed cell death and a highly organized physiological mechanism to destroy injured or abnormal cells. Apoptotic cells exhibit remarkable morphological features and characteristicExpand
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Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity
Curcumin (diferuloylmethane), a natural cancer chemopreventive compound, has been tested for its action in acute myeloblastic leukemia cell line HL-60. The results clearly show that curcumin inducesExpand
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Cytotoxic effect of root extract of Tiliacora racemosa and oil of Semecarpus anacardium nut in human tumour cells
Tiliacora racemosa and Semecarpus anacardium, the two plants frequently used in Ayurvedic medicine for the treatment of cancerous diseases, have been selected to examine their action in four humanExpand
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Reversal of resistance towards cisplatin by curcumin in cervical cancer cells.
Epigenetic regulators like histone deacetylases (1 and 2), and viral onco-proteins (E6/E7) are known to be overexpressed in cervical cancer cells. The present study was designed to investigate theExpand
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Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells.
Telomerase, a reverse transcriptase that maintains telomere length, is highly activated in tumor cells and practically absent in somatic cells and hence considered a potential marker forExpand
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Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal
Groundwater arsenic contamination has been a health hazard for West Bengal, India. Oxidative stress to DNA is recognized as an underlying mechanism of arsenic carcinogenicity. A phytochemical,Expand
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Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells
Isothiocyanates have potential chemopreventive and antitumor effects. In the present study, we examined the actions of PEITC and sulphoraphane in modulating the activity of protein kinase C (PKC) andExpand
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Curcumin augments the efficacy of antitumor drugs used in leukemia by modulation of heat shock proteins via HDAC6.
Heat shock proteins (HSPs) and histone deacetylase 6 (HDAC6) are induced under oxidative stress, which promotes oncogenesis. HSPs are regulated by heat shock factor1 (HSF1). HDAC6, a class IIbExpand
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Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate: a green tea polyphenol.
Modulation of events characteristic of carcinogenesis or of cancer cells is being emphasized as a rational strategy to control cancer. Green tea polyphenol epigallocatechin gallate (EGCG) has beenExpand
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Induction of Apoptosis in Tumor Cells by Natural Phenolic Compounds.
Investigation has been conducted to delineate the action of some phenolic compounds of natural origin in four human tumor cell lines: acute myeloblastic leukemia (HL-60), chronic myelogenic leukemiaExpand
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