• Publications
  • Influence
Eosinophilic esophagitis: updated consensus recommendations for children and adults.
A new conceptual definition is proposed highlighting that EoE represents a chronic, immune/antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Expand
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.
A multidisciplinary task force of 31 physicians assembled with the goal of determining diagnostic criteria and making recommendations for evaluation and treatment of children and adults with suspected eosinophilic esophagitis (EE) provided current recommendations for care of affected patients. Expand
Eosinophilic gastrointestinal disorders (EGID).
  • M. Rothenberg
  • Medicine
  • The Journal of allergy and clinical immunology
  • 2004
Preclinical studies have identified a contributory role for the cytokine IL-5 and the eotaxin chemokines, providing a rationale for specific disease therapy. Expand
Eosinophils: Biological Properties and Role in Health and Disease
The biology of eosinophils is summarized, focusing on transcriptional regulation of eOSinophil differentiation, characterization of the growing properties of eOsinophIL granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of Eosinophile degranulation. Expand
The eosinophil.
The molecular steps involved in eosinophil development and trafficking are described, with special attention to the important role of the transcription factor GATA-1, the eos inophil-selective cytokine IL-5, and the eotaxin subfamily of chemokines. Expand
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.
Eosinophilic esophagitis is an emerging disorder with a poorly understood pathogenesis and an empirical approach analyzing esophageal tissue by a genome-wide microarray expression analysis implicate eotaxin-3 as a critical effector molecule for EE and provide insight into disease pathogenesis. Expand
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.
Analysis of patients with asthma supported the importance of the ability of arginase to regulate generation of NO, polyamines, and collagen, and provided a basis for pharmacologically targeting arginine metabolism in allergic disorders. Expand
MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression 1
A miRNA signature in allergic airway inflammation is identified, which includes miR-21 that modulates IL-12, a molecule germane to Th cell polarization, which was decreased in IL-13 transgenic mice. Expand
Postnatal mammary gland development requires macrophages and eosinophils.
The data show that CSF1-regulated macrophages, in collaboration with eotaxin-regulated eosinophils, have essential and complementary functions in regulating the branching morphogenesis of the mammary gland. Expand
MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-γ Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity
It is shown that miR-21 has a central role in setting a balance between Th1 and Th2 responses to Ags, defining a new mechanism for regulating polarized immunoinflammatory responses. Expand