• Publications
  • Influence
The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.
TLDR
The findings suggest that psychological and pathological indices are closely related to one another, possibly through their common association with the underlying degenerative process in the brain. Expand
CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia.
  • M. Roth, E. Tym, +4 authors R. Goddard
  • Psychology, Medicine
  • The British journal of psychiatry : the journal…
  • 1 December 1986
TLDR
A new interview schedule for the diagnosis and measurement of dementia in the elderly is described, which is acceptable to patients, has a high inter-rater reliability and the cognitive section has been shown to have high and specificity. Expand
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
TLDR
A substantially enriched preparation of Alzheimer paired helical filaments has been used as a starting point for biochemical studies and sequence analysis of these peptides was used to design oligonucleotide probes for cloning a cognate cDNA, which leads to its identification as human microtubule-associated tau protein. Expand
CAMDEX : the Cambridge examination for mental disorders of the elderly
  • M. Roth
  • Medicine, Psychology
  • 13 June 1999
TLDR
Boxed set includes the schedule manual, the CAMCOG pictorial material, CDROM containing PDFs of the scoresheets, and abridged version of CAMDEX 1986 paper. Expand
The natural history of mental disorder in old age.
  • M. Roth
  • Psychology, Medicine
  • The Journal of mental science
  • 1 April 1955
TLDR
Examination of differences in pattern of outcome between specific groups provides strong confirmation for hypotheses suggesting that affective psychosis, late paraphrenia and acute confusion were each entities largely independent of the two main causes of progressive dementia in old age: senile and arteriosclerotic psychosis. Expand
THE DIAGNOSIS OF DEPRESSIVE SYNDROMES AND THE PREDICTION OF E.C.T. RESPONSE.
TLDR
An investigation of 129 in-patient depressives treated with E.C.T. supports the hypothesis that these are two distinct depressive populations and produces a bipolar factor corresponding to the distinction between endogenous and neurotic depression. Expand
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.
TLDR
It is shown that a similar proteolytically stable complex can be generated in vitro following the self-aggregation of tau protein through a high-affinity binding site in the repeat domain and that biologically selective pharmaceutical agents could be developed to facilitate the proteolytic degradation of tAU aggregates and prevent the further propagation of t Tau capture in AD. Expand
Observations on the brains of non-demented old people.
TLDR
Findings must be borne in mind when interpreting the changes in the brains of demented old people, or in the investigation of any other central nervous system disorder in old age. Expand
Environmental and hereditary factors in the schizophrenias of age ("late paraphrenia") and their bearing on the general problem of causation in schizophrenia.
TLDR
Except in one subgroup, referred to below, the clinical picture is remarkably uniform and is characterized by the presence of many schizophrenia like disorders of thought, mood and volition, by relatively good preservation of formal intellect, personality and memory. Expand
NEURONAL DEGENERATION IN LOCUS CERULEUS AND CORTICAL CORRELATES OF ALZHEIMER DISEASE
TLDR
The loss of nLC neurons was found to correlate significantly with norepinephrine concentration, choline acetyltransferase activity, and numbers of plaques and tangles, and changes in central noradrenergic pathways are related to the pathophysiology of AD. Expand
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