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A structural perspective of the flavivirus life cycle
The structural organization of these viruses and their associated structural proteins has provided insight into the molecular transitions that occur during the viral life cycle, such as assembly, budding, maturation and fusion. Expand
X-ray crystallographic structure of the Norwalk virus capsid.
The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure that has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that hasA classical eight-stranded beta-sandwich motif. Expand
Structure of Dengue Virus Implications for Flavivirus Organization, Maturation, and Fusion
The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map, suggesting that flaviviruses employ a fusion mechanism in which the distal beta barrels of domain II of the glycop Protein E are inserted into the cellular membrane. Expand
Structure of a human common cold virus and functional relationship to other picornaviruses
We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions haveExpand
Visualization of membrane protein domains by cryo-electron microscopy of dengue virus
The structure of mature dengue virus particles was determined to a resolution of 9.5 Å by cryo-EM and image reconstruction techniques, establishing the secondary structural disposition of the 180 envelope (E) and 180 membrane (M) proteins in the lipid envelope. Expand
The molecular replacement method.
  • M. Rossmann
  • Chemistry, Medicine
  • Acta crystallographica. Section A, Foundations of…
  • 1 February 1990
It is shown that the percentage of observed data and inaccuracy of the observed amplitudes available for phase extension are compensated by the extent of noncrystallographic redundancy and the fraction of crystal cell volume that may be flattened because it is outside the control of non Crystallographic symmetry. Expand
The 3.8 Å resolution cryo-EM structure of Zika virus
The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors that suggests that differences in this region may influence virus transmission and disease. Expand
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.
The structure of BVDV polymerase complexed with GTP, which is required for de novo (primer-independent) initiation, shows that GTP binds adjacent to the initiation NTP, suggesting that the GTP mimics aigial RNA product. Expand
The three-dimensional structure of canine parvovirus and its functional implications.
The three-dimensional atomic structure of a single-stranded DNA virus has been determined and some of the amino termini of VP-2 run to the exterior in full but not empty virions, which is consistent with the observation that someVP-2 polypeptides in full particles can be cleaved by trypsin. Expand
Structure of West Nile Virus
West Nile virus (WNV) is found throughout Africa, Europe, Central Asia, and, most recently, in North America, where there were 4156 outbreaks in 2002. Expand