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Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
- N. Enattah, Aimee Trudeau, +24 authors L. Peltonen
- Biology, Medicine
- American journal of human genetics
- 1 September 2007
The data about global allelic haplotypes of the lactose-tolerance variant imply that the T(-13910) allele has been independently introduced more than once and that there is a still-ongoing process of convergent evolution of the LP alleles in humans. Expand
Lactase haplotype frequencies in Caucasians: association with the lactase persistence/non‐persistence polymorphism
It appears that lactase persistence arose more recently than the DNA marker polymorphisms used here to define the main Caucasian haplotypes, possibly as a single mutation on the A haplotype background. Expand
The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element.
This work exploited known DNA 'marker' polymorphisms within the exons of the lactase gene to examine the expression of the individual lactase mRNA transcripts from persistent and non-persistent individuals in order to determine whether the regulation is in cis or trans. Expand
IgA antibodies to tissue transglutaminase: An effective diagnostic test for celiac disease.
OBJECTIVE Tissue transglutaminase (tTG) is the main autoantigen recognized by endomysial antibodies. The aim of this study was to assess sensitivity, specificity, and predictive value of IgA and IgG… Expand
Lactase persistence versus decline in human adults: multifactorial events are involved in down-regulation after weaning.
Both transcriptional and posttranscriptional factors cause the decline of intestinal lactase, and the single overriding factor distinguishing lactase-persistent subjects from hypolactasic subjects is the high rate of lactase biosynthesis. Expand
Interactive effects of fumonisin B1 and alpha-zearalenol on proliferation and cytokine expression in Jurkat T cells.
- D. Luongo, L. Severino, P. Bergamo, R. De Luna, A. Lucisano, M. Rossi
- Biology, Medicine
- Toxicology in vitro : an international journal…
- 1 December 2006
FB1 and alpha-ZEA showed different immunomodulation abilities when individually administered, and co-administration of mycotoxins resulted in further inhibition of both proliferation and IFN gamma mRNA expression. Expand
Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat
Mice fed a wheat-containing diet showed a higher incidence of diabetes, signs of small intestinal enteropathy and higher mucosal levels of proinflammatory cytokines. Expand
Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ
Purified CD IgA, IgG, as well as human anti-tTG monoclonal antibodies inhibited the enzymatic activity of human tTG both in vitro and in situ. Expand
A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway*
- Junki Miyamoto, Taichi Mizukure, +9 authors S. Tanabe
- Biology, Medicine
- The Journal of Biological Chemistry
- 10 December 2014
HYA modulates TNFR2 expression, at least partially, via the GPR40-MEK-ERK pathway and may be useful in the treatment of TJ-related disorders such as inflammatory bowel disease. Expand
Mycotoxins nivalenol and deoxynivalenol differentially modulate cytokine mRNA expression in Jurkat T cells.
Combination of NIV and DON at 1:1 and 1:10 ratios essentially restored the cytokine transcriptional pattern observed with NIV alone but the level of transcripts, with the exception of IL-8, peaked at lower concentrations suggesting interactive effects, confirming previous results and highlighting the usefulness of Jurkat as a T-cell model. Expand