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Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis.
More patients with hepatocellular carcinoma could be candidates for transplantation if the current dual approach to candidacy, based on the strict Milan criteria, were replaced with a more precise estimation of survival contouring individual tumour characteristics and use of the up-to-seven criteria. Expand
Nutritional status: its influence on the outcome of patients undergoing liver transplantation
- M. Merli, M. Giusto, +9 authors M. Rossi
- Liver international : official journal of the…
- 1 February 2010
The impact of the recipients' malnutrition on the outcome of liver transplantation (LT) is still under debate and recent studies have shown controversial results. Expand
Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again
- Q. Lai, F. Melandro, +6 authors F. Frattaroli
- International journal of hepatology
- 27 June 2012
None of these tests can be recommended to survey cirrhotic patients at risk for HCC development because of their suboptimal ability for routine clinical practice in HCC diagnosis, and the development of a new predictive model combining radiological and biological features based on biological markers is strongly required. Expand
Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets
The phenotypes and availability from all age donors suggest that these stem/progenitors have considerable potential for regenerative therapies of liver, bile duct, and pancreatic diseases including diabetes. Expand
Pregnancy after liver transplantation: report of 8 new cases and review of the literature.
The time intervals between transplantation and conception as well as the original cause of liver failure influence the outcome and complications of pregnancies in liver recipients, however, neonatal survival is high, while malformations are relatively rare. Expand
Alpha‐fetoprotein and modified response evaluation criteria in Solid Tumors progression after locoregional therapy as predictors of hepatocellular cancer recurrence and death after transplantation
- Q. Lai, A. Avolio, +7 authors J. Lerut
- Liver transplantation : official publication of…
- 1 October 2013
Both radiological and biological modifications permit documentation of the response to LRT in patients waiting for liver transplantation (LT) and, according to these 2 parameters, tumor progression significantly increases the risk of recurrence and patient death not only for MC‐OUT patients but also forMC‐IN patients. Expand
Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation.
- G. Carpino, S. Morini, +9 authors E. Gaudio
- Digestive and liver disease : official journal of…
- 1 May 2005
Results indirectly confirm that, in vivo, alpha-smooth muscle actin expression is a reliable marker of hepatic stellate cells activation which precedes fibrous tissue deposition even in the setting of recurrent HCV chronic hepatitis after liver transplantation, and it could be useful to identify the earliest stages of liver fibrosis and monitoring the efficacy of the therapy. Expand
Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages
The BTSCs are likely to be central to normal tissue turnover and injury repair and to be key elements in the pathophysiology of liver, pancreas and biliary tree diseases, including oncogenesis. Expand
Sperm-mediated gene transfer: production of pigs transgenic for a human regulator of complement activation.