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Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.
AIMS The present study was carried out to identify the cytochrome P450 isoenzyme(s) involved in the N-dealkylation of haloperidol (HAL). METHODS In vitro studies were performed using human liverExpand
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The pharmacokinetics of ciprofloxacin in patients with impaired renal function.
Pharmacokinetics of ciprofloxacin after single oral administration of 250 mg were studied in patients with and without renal failure. Ciprofloxacin concentrations were measured by HPLC. TheExpand
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Influence of Hypovolemia on the Pharmacokinetics and the Electroencephalographic Effect of Propofol in the Rat
BackgroundHypovolemia decreases the dose requirement for anesthetics, but no data are available for propofol. As it is impossible to study this in patients, a rat model was used in which theExpand
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Propofol combined with nitrous oxide‐oxygen for induction and maintenance of anaesthesia
After a bolus of 2 mg/kg, propofol was given by continuous infusion (150 μg/kg/minute for 30 minutes and then 100 μg/kg/minute) supplemented with nitrous oxide for anaesthesia during ear surgery inExpand
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Isosorbide, isomannide and isoidide dinitrate: urinary excretion in the rat.
Abstract In rats given the dinitrates of isosorbide, isomannide and isoidide orally, urinary excretion products were studied by gas chromatography and thin layer chromatography. The unchangedExpand
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Gas chromatography of the nitrate esters of glycerol, isosorbide and isomannide.
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Single dose pharmacokinetics of cetirizine in young and elderly volunteers.
The pharmacokinetics of the H1-receptor antagonist cetirizine were studied from 0 to 48 h after a single oral intake of 10 mg in 10 elderly volunteers (60 to 90 years) and in 10 young healthyExpand
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Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
The pharmacokinetics of three beta adrenoceptor blocking drugs atenolol, metoprolol, propranolol and of the model drug antipyrine were studied in 3-, 12- and 24-month-old rats. Alpha-1-acidExpand
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Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients.
The effects of smoking, CYP2D6 genotype, and concomitant use of enzyme inducers or inhibitors on the steady state plasma concentrations of haloperidol (HAL) and reduced haloperidol (RHAL) wereExpand
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Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat.
The influence of endotoxin-induced inflammation on the enantioselective pharmacokinetics of propranolol, oxprenolol, and verapamil, which bind to alpha 1-acid glycoprotein, was studied in the rat.Expand
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