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Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.
- L. Pan, P. Wijnant, C. D. de Vriendt, M. Rosseel, F. Belpaire
- Chemistry, Medicine
- British journal of clinical pharmacology
- 2 October 2003
AIMS The present study was carried out to identify the cytochrome P450 isoenzyme(s) involved in the N-dealkylation of haloperidol (HAL). METHODS In vitro studies were performed using human liver… Expand
The pharmacokinetics of ciprofloxacin in patients with impaired renal function.
- J. Boelaert, Y. Valcke, +4 authors M. Bogaert
- The Journal of antimicrobial chemotherapy
- 1 July 1985
Pharmacokinetics of ciprofloxacin after single oral administration of 250 mg were studied in patients with and without renal failure. Ciprofloxacin concentrations were measured by HPLC. The… Expand
Influence of Hypovolemia on the Pharmacokinetics and the Electroencephalographic Effect of Propofol in the Rat
- P. De Paepe, F. Belpaire, M. Rosseel, G. Van Hoey, P. Boon, W. Buylaert
- 1 December 2000
BackgroundHypovolemia decreases the dose requirement for anesthetics, but no data are available for propofol. As it is impossible to study this in patients, a rat model was used in which the… Expand
Propofol combined with nitrous oxide‐oxygen for induction and maintenance of anaesthesia
After a bolus of 2 mg/kg, propofol was given by continuous infusion (150 μg/kg/minute for 30 minutes and then 100 μg/kg/minute) supplemented with nitrous oxide for anaesthesia during ear surgery in… Expand
Isosorbide, isomannide and isoidide dinitrate: urinary excretion in the rat.
Abstract In rats given the dinitrates of isosorbide, isomannide and isoidide orally, urinary excretion products were studied by gas chromatography and thin layer chromatography. The unchanged… Expand
Gas chromatography of the nitrate esters of glycerol, isosorbide and isomannide.
Single dose pharmacokinetics of cetirizine in young and elderly volunteers.
The pharmacokinetics of the H1-receptor antagonist cetirizine were studied from 0 to 48 h after a single oral intake of 10 mg in 10 elderly volunteers (60 to 90 years) and in 10 young healthy… Expand
Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
- F. Belpaire, F. De Smet, +4 authors L. Chauvelot-Moachon
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 July 1990
The pharmacokinetics of three beta adrenoceptor blocking drugs atenolol, metoprolol, propranolol and of the model drug antipyrine were studied in 3-, 12- and 24-month-old rats. Alpha-1-acid… Expand
Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients.
- L. Pan, R. V. Vander Stichele, M. Rosseel, J. Berlo, N. De Schepper, F. Belpaire
- Therapeutic drug monitoring
- 1 October 1999
The effects of smoking, CYP2D6 genotype, and concomitant use of enzyme inducers or inhibitors on the steady state plasma concentrations of haloperidol (HAL) and reduced haloperidol (RHAL) were… Expand
Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat.
The influence of endotoxin-induced inflammation on the enantioselective pharmacokinetics of propranolol, oxprenolol, and verapamil, which bind to alpha 1-acid glycoprotein, was studied in the rat.… Expand