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Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries
Despite the ever-increasing output of Illumina sequencing data, loci with extreme base compositions are often under-represented or absent. To evaluate sources of base-composition bias, we tracedExpand
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Characterizing and measuring bias in sequence data
BackgroundDNA sequencing technologies deviate from the ideal uniform distribution of reads. These biases impair scientific and medical applications. Accordingly, we have developed computationalExpand
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Medulloblastomas are the most common malignant brain tumours in children. Identifying and understanding the genetic events that drive these tumours is critical for the development of more effectiveExpand
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Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition.
The degree of nutrient enhancement during the newborn period may modulate programming of appetite-regulating hormones, body composition, and propensity to adult obesity in intrauterineExpand
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Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain.
Perinatal infections are a risk factor for fetal neurological pathologies, including cerebral palsy and schizophrenia. Cytokines that are produced as part of the inflammatory response are proposed toExpand
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Maternal Undernutrition Influences Placental-Fetal Development1
Maternal nutrition during pregnancy has a pivotal role in the regulation of placental-fetal development and thereby affects the lifelong health and productivity of offspring. Suboptimal maternalExpand
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Epigenomics, gestational programming and risk of metabolic syndrome
Epigenetic mechanisms are emerging as mediators linking early environmental exposures during pregnancy with programmed changes in gene expression that alter offspring growth and development. There isExpand
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Covid-19 and Kidney Transplantation
Kidney-Transplant Recipients with Covid-19 A cohort of 36 consecutive kidney-transplant recipients had less fever, lower CD3, CD4, and CD8 cell counts, more rapid clinical deterioration, and a high...
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Estimating perception of scene layout properties from global image features.
The relationship between image features and scene structure is central to the study of human visual perception and computer vision, but many of the specifics of real-world layout perception remainExpand
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Adult sequelae of intrauterine growth restriction.
Fetal intrauterine growth restriction has been associated with adult disease in both human epidemiologic studies and in animal models. In some cases, intrauterine deprivation programs the fetus toExpand
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