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Simple device for the direct visualization of oral-cavity tissue fluorescence.
A robust, field-of-view device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions and is envisaged as a suitable adjunct for oral cancer screening, biopsy guidance, and margin delineation. Expand
Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.
  • M. Rosin, X. Cheng, +8 authors L. Zhang
  • Medicine, Biology
  • Clinical cancer research : an official journal of…
  • 1 February 2000
Analysis of LOH at 3p and 9p could serve as an initial screening for cancer risk of early premalignancies and follow-up investigation for additional losses would be essential for predicting cancer progression. Expand
Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients
These data have, for the first time, shown that direct FV can identify subclinical high-risk fields with cancerous and precancerous changes in the operating room setting. Expand
Loss of Heterozygosity (LOH) Profiles—Validated Risk Predictors for Progression to Oral Cancer
Multicovariate analysis with clinical features showed LOH models to be the most significant predictors of progression in the largest longitudinal study to date of low-grade OPLs from a population-based patient group. Expand
3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites.
The identification of 3p and 9p loss in posttreatment lesions could serve as a simple and direct test for stratifying risk of SOM development. Expand
Advances in the diagnosis of oral premalignant and malignant lesions.
Advances in diagnosis and staging at the molecular level are expected to affect choice of treatment and patient outcomes and oral health care providers should be aware of these advances in the evaluation and diagnosis. Expand
Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome.
Toluidine blue-positive staining correlated with clinicopathologic risk factors and high-risk molecular risk patterns and a >6-fold elevation in cancer risk was observed for toluidine blue- positive lesions, with positive retention of the dye present in 12 of the 15 lesions that later progressed to cancer. Expand
Direct fluorescence visualization of clinically occult high‐risk oral premalignant disease using a simple hand‐held device
A considerable proportion of oral cancer and precancer is not clinically apparent and could contribute significantly to the late diagnosis and high mortality of oral cancer. A simple method toExpand
Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta‐carotene and with beta‐carotene plus vitamin A
Fishermen from Kerala (India) who chewed tobacco‐containing betel quids daily (17.2 ± 9.6 quids per day) and had well‐developed oral leukoplakias with elevated frequencies of micronucleated cellsExpand
Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells
The micronucleus test was applied to exfoliated cells of the buccal mucosa of four population groups: (A) non‐smokers and non‐drinkers of alcoholic beverages, (B) non‐smokers but alcohol drinkers,Expand