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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These dataExpand
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Role of transcription factors a Brn-3.1 and Brn-3.2 in auditory and visual system development
THE neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1–6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene7 that constitute, with Brn-3.0 (refs 1–3,8,9), the class IV POU-domainExpand
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Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitoninExpand
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Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Alternative processing of the RNA transcribed from the calcitonin gene appears to result in the production of a messenger RNA in neural tissue distinct from that in thyroidal ‘C’ cells. The thyroidExpand
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Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation
NEUROBIOLOGY. For the article ‘‘Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation’’ by Dmitriy A. Yablonskiy, Joseph J. H. Ackerman, andExpand
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Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes
A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the structural gene of rat growth hormone was microinjected into the pronuclei of fertilized mouse eggs. Of 21 miceExpand
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Model of forebrain regionalization based on spatiotemporal patterns of POU‐III homeobox gene expression, birthdates, and morphological features
In situ hybridization was used to map spatiotemporal expression patterns of the four known intronless POU‐III transcription factor genes Brn‐1, Brn‐2, Brn‐4, and Tst‐1 in the developing rat forebrainExpand
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Expression of a large family of POU-domain regulatory genes in mammalian brain development
Nature 34O, 35-42 (1989). IN this Article there is an error in the amino acid sequence encoded by Tst-1 gene (hybridizing to 7.6, 4.4, 3.2 and 2.4Kb brain mRNAs) reported in Fig. 16, two residuesExpand
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LPS induces KH‐type splicing regulatory protein‐dependent processing of microRNA‐155 precursors in macrophages
The importance of post‐transcriptional mechanisms for the regulation of the homoeostasis of the immune system and the response to challenge by microorganisms is becoming increasingly appreciated. WeExpand
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