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Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
TLDR
The purified protein reproduced two additional effects of PTH, stimulation of bone resorption in fetal rat limb bone cultures and inhibition of phosphate uptake in cultured opossum kidney cells, consistent with a role for PTH-like proteins as mediators of the syndrome of malignancy-associated hypercalcemia. Expand
Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy.
TLDR
Results indicate that receptor occupancy, rather than receptor-mediated signaling, is necessary, although not sufficient, for endocytosis of the hPTH1-Rc and that Activation of PKC, however, is absolutely required. Expand
Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis.
TLDR
A model of in vivo hBMSC migration from a physiologic human bone environment to human breast tumors is presented and, at the primary tumor level, interleukin 17B/IL-17BR signaling may mediate interactions between hB MSCs and breast cancer cells. Expand
A mouse model of human breast cancer metastasis to human bone.
TLDR
An animal model of breast cancer metastasis in which the breast cancer cells and the bone target of osteotropic metastasis are both of human origin is developed and serves as a useful and relevant model for studying the disease. Expand
Parathyroid Hormone-Receptor Interactions Identified Directly by Photocross-linking and Molecular Modeling Studies*
TLDR
Molecular modeling and photocross-linking and molecular modeling studies provide insight into the topologic arrangement of the receptor-ligand complex strongly supports Met425, at the extracellular end of transmembrane helix 6, as the residue interacting with the N-terminal residue of the hPTH-(1–34). Expand
Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone.
TLDR
It is shown that ROCK expression is increased in metastatic human mammary tumors and breast cancer cell lines compared with nonmetastatic tumors and cell lines, and inhibition of ROCK activity, by either a specific ROCK inhibitor (Y27632) or ROCK-targeted small interfering RNAs, reduces cell migration and proliferation in vitro and metastasis to bone in vivo. Expand
Photoaffinity Cross-linking Identifies Differences in the Interactions of an Agonist and an Antagonist with the Parathyroid Hormone/Parathyroid Hormone-related Protein Receptor*
TLDR
Analysis of the digestion profiles of the ligand-receptor photoconjugates revealed that both the agonist and the antagonist cross-link to the S-CH3 group of Met425 in transmembrane domain 6 of the human PTH/PTHrP receptor, suggesting that the antagonist Bpa2-PTHRP is able to distinguish between two distinct conformations of the receptor. Expand
The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation.
TLDR
It is proposed that the mid-region of PTH-(1-34) has a role in fixing, by extensive contacts with the receptor, the entry of the N-terminal helix of the hormone into the heptahelical bundle between TM-1 and TM-2. Expand
Physical conditioning facilitates the exercise-induced secretion of beta-endorphin and beta-lipotropin in women.
TLDR
A large number of healthy persons participate in strenuous sports, but the mechanisms by which exercise produces various clinical... Expand
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