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Obesity is associated with macrophage accumulation in adipose tissue.
TLDR
Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass. Expand
Changes in energy expenditure resulting from altered body weight.
TLDR
Maintenance of a reduced or elevated body weight is associated with compensatory changes in energy expenditure, which oppose the maintenance of a body weight that is different from the usual weight, which may account for the poor long-term efficacy of treatments for obesity. Expand
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
TLDR
It is proposed that SirT1-dependent P parγ deacetylation is a form of selective Pparγ modulation of potential therapeutic import in order to staunch the current obesity epidemic. Expand
The Long-Term Stability of the Human Gut Microbiota
TLDR
Low-error sequencing data suggest that initial microbial colonizers of infant guts could persist over the life span of an individual, and members of Bacteroidetes and Actinobacteria are significantly more stable components than the population average. Expand
NIH working group report: Innovative research to improve maintenance of weight loss
TLDR
A working group of experts in integrative physiology and behavioral psychology was convened with the goal of merging their perspectives regarding the barriers to scientific progress and the development of novel ways to improve long‐term outcomes in obesity therapeutics. Expand
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight.
TLDR
During leptin administration, energy expenditure, skeletal muscle work efficiency, sympathetic nervous system tone, and circulating concentrations of thyroxine and triiodothyronine returned to pre-weight-loss levels, suggesting that the weight-reduced state may be regarded as a condition of relative leptin insufficiency. Expand
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.
TLDR
Following weight loss, there were predictable changes in neural activity, many of which were reversed by leptin, in brain areas known to be involved in the regulatory, emotional, and cognitive control of food intake, consistent with a model of the weight-reduced state as one of relative leptin deficiency. Expand
Effects of gender, body composition, and menopause on plasma concentrations of leptin.
TLDR
While plasma [leptin], corrected for FM, declines significantly in women post-menopause, this decline is not sufficient to account for the striking sexual dimorphism in the relationship of leptin to fat mass. Expand
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects.
TLDR
Examination of skeletal muscle work efficiency by graded cycle ergometry and rates of gastrocnemius muscle ATP flux during exercise by magnetic resonance spectroscopy found changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity. Expand
Estimating the changes in energy flux that characterize the rise in obesity prevalence.
TLDR
This relation suggests that substantial increases in TEI have driven the increases in body weight over the past 3 decades and the obesity epidemic will not be reversed without large reductions in energy intake, increases in physical activity, or both. Expand
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