Obesity is associated with macrophage accumulation in adipose tissue.
- S. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. Leibel, A. Ferrante
- Biology, MedicineJournal of Clinical Investigation
- 15 December 2003
Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
Changes in energy expenditure resulting from altered body weight.
- R. Leibel, M. Rosenbaum, J. Hirsch
- MedicineNew England Journal of Medicine
- 9 March 1995
Maintenance of a reduced or elevated body weight is associated with compensatory changes in energy expenditure, which oppose the maintenance of a body weight that is different from the usual weight, which may account for the poor long-term efficacy of treatments for obesity.
The Long-Term Stability of the Human Gut Microbiota
Low-error sequencing data suggest that initial microbial colonizers of infant guts could persist over the life span of an individual, and members of Bacteroidetes and Actinobacteria are significantly more stable components than the population average.
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
- L. Qiang, Liheng Wang, D. Accili
- BiologyCell
- 3 August 2012
NIH working group report: Innovative research to improve maintenance of weight loss
- P. MacLean, R. Wing, D. Ryan
- MedicineObesity
- 1 January 2015
A working group of experts in integrative physiology and behavioral psychology was convened with the goal of merging their perspectives regarding the barriers to scientific progress and the development of novel ways to improve long‐term outcomes in obesity therapeutics.
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.
- M. Rosenbaum, M. Sy, Katherine H. Pavlovich, R. Leibel, J. Hirsch
- Psychology, BiologyJournal of Clinical Investigation
- 1 July 2008
Following weight loss, there were predictable changes in neural activity, many of which were reversed by leptin, in brain areas known to be involved in the regulatory, emotional, and cognitive control of food intake, consistent with a model of the weight-reduced state as one of relative leptin deficiency.
Effects of gender, body composition, and menopause on plasma concentrations of leptin.
- M. Rosenbaum, M. Nicolson, R. Leibel
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 September 1996
While plasma [leptin], corrected for FM, declines significantly in women post-menopause, this decline is not sufficient to account for the striking sexual dimorphism in the relationship of leptin to fat mass.
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight.
- M. Rosenbaum, R. Goldsmith, R. Leibel
- Biology, MedicineJournal of Clinical Investigation
- 1 December 2005
During leptin administration, energy expenditure, skeletal muscle work efficiency, sympathetic nervous system tone, and circulating concentrations of thyroxine and triiodothyronine returned to pre-weight-loss levels, suggesting that the weight-reduced state may be regarded as a condition of relative leptin insufficiency.
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects.
- M. Rosenbaum, K. Vandenborne, R. Leibel
- MedicineAmerican Journal of Physiology. Regulatory…
- 1 July 2003
Examination of skeletal muscle work efficiency by graded cycle ergometry and rates of gastrocnemius muscle ATP flux during exercise by magnetic resonance spectroscopy found changes in muscle efficiency at altered body weight accounted for 35% of the change in daily energy expended in physical activity.
Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men.
- K. Hall, Kong Y. Chen, E. Ravussin
- MedicineAmerican Journal of Clinical Nutrition
- 6 July 2016
The isocaloric KD was not accompanied by increased body fat loss but was associated with relatively small increases in EE that were near the limits of detection with the use of state-of-the-art technology.
...
...