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Long-Term Experimental Evolution in Escherichia coli. I. Adaptation and Divergence During 2,000 Generations
TLDR
The degree to which adaptation to a uniform environment among independently evolving asexual populations is associated with increasing divergence of those populations is assessed, consistent with theoretical expectations that do not invoke divergence due to multiple fitness peaks in a Wrightian evolutionary landscape.
Long-term experimental evolution in Escherichia coli
TLDR
The degree to which adaptation to a uniform environment among independently evolving asexual populations is associated with increasing divergence of those populations is assessed, which is consistent with theoretical expectations that do not invoke divergence due to multiple fitness peaks in a Wrightian evolutionary landscape.
LABORATORY EVOLUTION OF POSTPONED SENESCENCE IN DROSOPHILA MELANOGASTER
  • M. Rose
  • Biology
    Evolution; international journal of organic…
  • 1 September 1984
TLDR
It would be misleading to claim that all relevant experimental results directly corroborate the evolutionary theory of senescence, but there are two corollaries which follow from the general theory itself: the reproductive schedule of an outbred population will give rise to natural selection acting to accelerate senescences in populations with a relatively earlier age of reproduction and postpone senescenced populations.
Physiological mechanisms of evolved desiccation resistance in Drosophila melanogaster.
TLDR
Although excretory water loss was reduced in desiccation-selected flies, it comprised less than 10% of total water loss, indicating that the D populations have evolved reduced cuticular and/or respiratory water loss rates.
Evolution of senescence: late survival sacrificed for reproduction.
  • T. Kirkwood, M. Rose
  • Biology
    Philosophical transactions of the Royal Society…
  • 29 April 1991
TLDR
The antagonistic pleiotropy theory proposes that certain alleles that are favoured because of beneficial early effects also have deleterious later effects, and the disposable soma theory suggests that because of the competing demands of reproduction less effort is invested in the maintenance of somatic tissues than is necessary for indefinite survival.
Genome-wide analysis of a long-term evolution experiment with Drosophila
Experimental evolution systems allow the genomic study of adaptation, and so far this has been done primarily in asexual systems with small genomes, such as bacteria and yeast. Here we present
COMPLEX TRADE‐OFFS AND THE EVOLUTION OF STARVATION RESISTANCE IN DROSOPHILA MELANOGASTER
TLDR
This study implicates multiple life‐cycle stages in the response to selection for the stress resistance of only one stage, and shows that patterns of genetic correlation may prove misleading unless multiple pleiotropic interconnections are resolved.
How to select outcome measurement instruments for outcomes included in a “Core Outcome Set” – a practical guideline
TLDR
This study resulted in a consensus-based guideline on the methods for selecting outcome measurement instruments for outcomes included in a COS, which can be used by COS developers in defining how to measure core outcomes.
Metabolic Reserves and Evolved Stress Resistance in Drosophila melanogaster
TLDR
The results demonstrate that the flies responded to selection for starvation resistance through a genetically determined increase in both lipid and carbohydrate storage, and suggest that different forms of stress are resisted with distinct physiological mechanisms and that the evolutionary response of the flies to stress selection is specific to the stress imposed.
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