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Coupled oscillators control morning and evening locomotor behaviour of Drosophila
It is shown that the timing of morning and Evening activity in Drosophila derives from two distinct groups of circadian neurons: morning activity from the ventral lateral neurons that express the neuropeptide PDF, and evening activity from another group of cells, including the dorsal lateral neurons.
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila.
The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila
A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila.
- J. Park, C. Helfrich-Förster, G. Lee, L. Liu, M. Rosbash, J. C. Hall
- BiologyProceedings of the National Academy of Sciences…
- 28 March 2000
Results reveal PDF as an important circadian mediator whose expression and function are downstream of the clockworks, and separate elements of the central pacemaking machinery regulate pdf or its product in novel and different ways.
CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
Observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of each per gene product causes cycling of its own RNA.