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Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology.
Current knowledge on the structure, enzymology, genetics, regulation and pathophysiology of mammalian molybdo-flavoenzymes is summarized. Expand
Cellulosome assembly revealed by the crystal structure of the cohesin–dockerin complex
The structure provides an explanation for the lack of cross-species recognition between cohesin–dockerin pairs and thus provides a blueprint for the rational design, construction, and exploitation of these catalytic assemblies. Expand
Xyloglucan Is Recognized by Carbohydrate-binding Modules That Interact with β-Glucan Chains*
It is shown that the C-terminal domain of the modular Clostridium thermocellum enzyme CtCel9D-Cel44A comprises a novel CBM (designated CBM44) that binds with equal affinity to cellulose and xyloglucan, and that accommodation of xylglucan side chains is a general feature of CBMs that bind to single cellulose chains. Expand
Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase.
The first crystal structures of human AOX1 are reported, substrate free and in complex with the substrate phthalazine and the inhibitor thioridazine, revealing a new, unexpected and fully occupied inhibitor-binding site that is structurally conserved among mammalian AOXs and XO. Expand
Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization.
DHDPS catalyses the condensation of pyruvate and aspartate beta-semialdehyde by a ping-pong mechanism, and the density of the crystals indicates the presence of a dimer of DHDPS subunits per asymmetric unit. Expand
The First Mammalian Aldehyde Oxidase Crystal Structure
The mouse liver aldehyde oxidase 3 three-dimensional structure combined with kinetic, mutagenesis data, molecular docking, and molecular dynamics studies make a decisive contribution to understand the molecular basis of its rather broad substrate specificity. Expand
Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas
The crystal structure of the aldehyde oxido-reductase (Mop) from the sulfate reducing anaerobic Gram-negative bacterium Desulfovibrio gigas has been determined at 2.25 Å resolution by multipleExpand
Crystal structure of the first dissimilatory nitrate reductase at 1.9 A solved by MAD methods.
The polypeptide fold of NAP and the arrangement of the cofactors is related to that of Escherichia coli formate dehydrogenase (FDH) and distantly resembles dimethylsulphoxide reductase. Expand
Mo and W bis-MGD enzymes: nitrate reductases and formate dehydrogenases
This review discusses in this review the information of the better characterized examples of these two types of Mo enzymes and W enzymes closely related to the members of the DMSO reductase family. Expand
Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA.
Horse prostate kallikrein (HPK) is the first structure of a serine protease purified from seminal plasma and shares extensive sequence homology with human prostate-specific antigen (PSA), including a predicted chymotrypsin-like specificity. Expand