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Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region
- M. Rodriguez, J. Leibowitz, C. David
- Biology, MedicineThe Journal of experimental medicine
- 1 March 1986
The findings in the congeneic recombinant mice and in mice mutant in the H-2D region strongly suggest that at least one of the genes critical for determining virus-induced demyelination maps to the 3' end of the H2D gene.
A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases.
- C. Lucchinetti, W. Brück, J. Parisi, B. Scheithauer, M. Rodriguez, H. Lassmann
- BiologyBrain : a journal of neurology
- 1 December 1999
The profound heterogeneity in extent and topography of OG destruction in active demyelinating lesions suggests that in subsets of multiple sclerosis patients, myelin, mature OGs and possibly OG progenitors are differentially affected.
Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
The observations support the hypothesis that susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination is influenced by genes that are linked to the H-2 complex and suggest that the demYelination may be mediated by immune cells rather than being a direct cytolytic effect of virus on oligodendrocytes.
Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis.
- A. Warrington, K. Asakura, M. Rodriguez
- BiologyProceedings of the National Academy of Sciences…
- 6 June 2000
The results are consistent with the hypothesis that CNS-reactive mAbs, part of the normal Ig repertoire in humans, may help repair and protect the CNS from pathogenic immune injury, and further challenge the premise that Abs that bind OLs are necessarily pathogenic.
Expression of Major Histocompatibility Complex class l Molecules on the Different Cell Types in Multiple Sclerosis Lesions
Examination of expression of functional MHC class I molecule complex in a large sample of human autopsy material indicates that in MS lesions all cells of the central nervous system are potential targets for Class I MHC restricted cytotoxic T‐cells.
Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.
It is provided a hypothesis that the specificity of primary white matter destruction in the TMEV model depends on immune-sensitized cells which interact with viral antigen plus major histocompatibility complex (MHC) antigens on the surfaces of oligodendrocytes or myelin sheaths.
Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus
It is demonstrated that virus-specific CTLs are present in the CNS of chronically infected SJL/J mice during both acute and chronic TMEV infection, arguing against the hypothesis that the ability to generate CD8+ C TLs mediates resistance.
Ultrastructure of multiple sclerosis.
It is concluded that disturbance of the myelinating function of oligodendrocytes may be a critical event in the pathogenesis of multiple sclerosis.
Paraneoplastic anti-Purkinje and type I anti-neuronal nuclear autoantibodies bind selectively to central, peripheral, and autonomic nervous system cells.
- H. Altermatt, M. Rodriguez, B. Scheithauer, V. Lennon
- Biology, MedicineLaboratory investigation; a journal of technical…
It is apparent that PCAb and ANNA-I represent at least a component of an immune response that is initiated by tumor antigens in the nervous system, and are consistent with the diversity of neurologic manifestations that can occur in individual patients with the associated paraneoplastic syndromes.