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Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.
- Mark P. Jedrychowski, C. Wrann, +6 authors B. Spiegelman
- Chemistry, Medicine
- Cell metabolism
- 6 October 2015
This precise state-of-the-art method shows that human irisin is mainly translated from its non-canonical start codon and circulates at ∼ 3.6 ng/ml in sedentary individuals; this level is increased to ∼ 4.3 ng/ ml in individuals undergoing aerobic interval training. Expand
Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.
It is reported that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic capacity and skeletal muscle mitochondrial respiration. Expand
Long‐term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are not altered by protein supplementation
- M. Robinson, S. Turner, M. Hellerstein, K. Hamilton, B. Miller
- Biology, Medicine
- FASEB journal : official publication of the…
- 25 May 2011
It is concluded that postexercise protein supplementation does not increase rates of mixed protein synthesis over 6 wk and that aerobic exercise may stimulate long‐term cell division (DNA synthesis) in skeletal muscle of humans. Expand
Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.
- M. Johnson, B. Irving, +12 authors K. Nair
- The journals of gerontology. Series A, Biological…
- 1 November 2015
In conclusion aging is associated with an inability to improve skeletal muscle and mitochondrial protein quality in response to ET by increasing degradation of damaged proteins, which does however increase Muscle and mitochondrial antioxidant capacity in older individuals, which provides increased buffering from the acute oxidative effects of exercise. Expand
Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis.
It is found that CR decreases oxidant emission, increases antioxidant scavenging, and minimizes oxidative damage to DNA and protein, which demonstrates that CR preserves mitochondrial function by protecting the integrity and function of existing cellular components rather than by increasing mitochondrial biogenesis. Expand
Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults
A role for TXNIP is supported in mediating the improvement in peripheral insulin sensitivity after CR, which lowered insulin-stimulated thioredoxin-interacting protein (TXNIP) levels and enhanced nonoxidative glucose disposal. Expand
Skeletal muscle aging and the mitochondrion
increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population. Expand
Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults
It is demonstrated that n3-PUFA reduce mitochondrial oxidant emissions, increase postabsorptive muscle protein synthesis, and enhance anabolic responses to exercise in older adults. Expand
Impact of improved cookstoves on indoor air pollution and adverse health effects among Honduran women
- M. Clark, J. Peel, +5 authors S. Reynolds
- Environmental Science, Medicine
- International journal of environmental health…
- 4 September 2009
There was no evidence of associations between cookstove type or air quality measures with lung function or CRP, and women using traditional stoves reported symptoms more frequently than those using improved stoves. Expand
Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans.
- Antigoni Z. Lalia, S. Dasari, +8 authors I. Lanza
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 February 2016
The reduction in insulin sensitivity observed with aging is driven primarily by age-related changes in the content and distribution of adipose tissue and is independent of muscle mitochondrial function or chronological age. Expand