• Publications
  • Influence
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype
Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish, and reconstructs much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype. Expand
The amphioxus genome and the evolution of the chordate karyotype
Whole-genome comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also partial reconstruction of its genomic organization. Expand
RRTree: Relative-Rate Tests between groups of sequences on a phylogenetic tree
UNLABELLED RRTree is a user-friendly program for comparing substitution rates between lineages of protein or DNA sequences, relative to an outgroup, through relative rate tests. Genetic diversity isExpand
Evidence for two distinct functional glucocorticoid receptors in teleost fish.
Results indicate that these two GR sequences encode for two functionally distinct GRs acting as ligand-inducible transcription factors in rainbow trout. Expand
Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita
The draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, is reported, providing insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies. Expand
Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.
Notably, differential gene loss played an important role in the evolution of different nuclear receptor sets in bilaterian lineages and was also shaped by periods of gene duplication in vertebrates, as well as a lineage-specific duplication burst in nematodes. Expand
Gene loss and evolutionary rates following whole-genome duplication in teleost fishes.
By phylogenetic analysis, the evolutionary origin of 675 Tetraodon duplicated genes assigned to chromosomes are determined, showing that similar mechanisms are at work in fishes as in yeast or plants and provide a framework for future investigation of the consequences of duplication in fishes and other animals. Expand
The nuclear receptor superfamily
Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development andExpand
The amphioxus genome illuminates vertebrate origins and cephalochordate biology.
The results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates. Expand
Evidence for polygenic adaptation to pathogens in the human genome.
The results show that past interactions with pathogens have elicited widespread and coordinated genomic responses, and suggest that adaptation to pathogens can be considered as a primary example of polygenic selection. Expand