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Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment
Drug-induced valvular heart disease (VHD) is a serious side effect of a few medications, including some that are on the market. Pharmacological studies of VHD-associated medications (e.g.,Expand
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Protein labeling with FlAsH and ReAsH.
The ability to image biochemical and phenotypical changes in living cells has become crucial for the investigation and understanding of the molecular mechanisms that govern all physiological cellularExpand
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Mutational Analysis of ThiH, a Member of the Radical S-Adenosylmethionine (AdoMet) Protein Superfamily*
Thiamine pyrophosphate (TPP) is an essential cofactor for all forms of life. In Salmonella enterica, the thiH gene product is required for the synthesis of the 4-methyl-5-β hydroxyethyl-thiazoleExpand
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Fluorescent labeling of proteins in living cells using the FKBP12 (F36V) tag
Over the past decade live cell imaging has become a key technology to monitor and understand the dynamic behavior of proteins in the physiological context of living cells. The visualization of aExpand
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A one-arm homologous recombination approach for developing nuclear receptor assays in somatic cells.
Drug discovery is in need of technologies that enable investigators to develop cell-based assays that accurately reflect the functional consequence of small molecule intervention on biologicalExpand
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Abstract 4867: High-throughput LanthaScreen® cellular assays for interrogating post-translational modifications of p53 and histones
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Post-translational modifications such as phosphorylation, acetylation and ubquitination play important roles inExpand
Abstract C224: Identification of drug targets via their intracellular interactions.
Phenotypic-based screening of small molecule libraries is a significant trend in drug discovery. However, deciphering the intracellular interactions between proteins and small molecules that mediateExpand