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Radiation-induced brain injury: A review
TLDR
There is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their integration at clinically relevant doses and schedules. Expand
Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter.
TLDR
It is demonstrated that PPARgamma can alter catalase expression; this occurs via a PPRE in the rat catal enzyme promoter, and hence down-regulating the inflammatory response via scavenging of reactive oxygen species. Expand
Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study.
TLDR
While ACE inhibitors as a class do not appear to be independently associated with dementia risk or cognitive decline in older hypertensive adults, there may be within-class differences in regard to these outcomes. Expand
Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration
TLDR
It is found that satellite cells, expressing dystroglycan, support continued efficient regeneration of skeletal muscle along with transient expression of dystrophin-glycoprotein complex in differentiated muscle and in regenerating muscle fibers in a mild form of human muscular dystrophy caused by disruption of posttranslational dystoglycan processing. Expand
Chronic oxidative stress and radiation‐induced late normal tissue injury: a review
TLDR
A growing body of evidence appears to support the hypothesis that chronic oxidative stress might serve to drive the progression of radiation‐induced late effects, and provides the foundation for antioxidant‐based interventional approaches directed at modulating late normal tissue injury. Expand
Animal Models for Medical Countermeasures to Radiation Exposure
TLDR
Investigators from each of the CMCRs organized and met for an Animal Models Workshop, which discussed the wide range of animal models available for assessing agent efficacy in a number of relevant tissues and organs, including the immune and hematopoietic systems. Expand
RADIATION NEPHROPATHY
TLDR
The classic view of radiation nephropathy being inevitable, progressive, and untreatable because of DNA damage-mediated cell loss at division has been replaced by a new paradigm in which radiation-induced injury involves not only direct cell kill but also involves complex and dynamic interactions between glomerular, tubular, and interstitial cells. Expand
Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications.
TLDR
The effectiveness of renin-angiotensin system blockers, peroxisome proliferator-activated receptor (PPAR) gamma agonists, and antioxidants/antioxidant enzymes in preventing or mitigating the severity of radiation- induced late effects indicates that radiation-induced chronic injury can be prevented and/or treated. Expand
Oxidative damage pathways in relation to normal tissue injury.
TLDR
It is hypothesized that the effectiveness of renin-angiotensin system blockers in preventing or mitigating the severity of radiation-induced late effects reflects, in part, inhibition of reactive oxygen species generation and the resultant chronic oxidative stress. Expand
Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life.
TLDR
Cognitive functioning, mood, and health-related QOL were significantly improved following a 24-week course of the acetylcholinesterase inhibitor donepezil in irradiated brain tumor patients. Expand
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