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Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism
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Transgenic Mice Reveal Unexpected Diversity of On-Off Direction-Selective Retinal Ganglion Cell Subtypes and Brain Structures Involved in Motion Processing
TLDR
Two genetically identified populations of On-Off DSGCs are compared and it is found that although both populations are tuned for posterior motion, they can be distinguished by a variety of physiological and anatomical criteria.
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Dopamine Replacement Therapy Does Not Restore the Full Spectrum of Normal Pallidal Activity in the 1-Methyl-4-Phenyl-1,2,3,6-Tetra-Hydropyridine Primate Model of Parkinsonism
TLDR
It is suggested that the tremor characteristics after exposure to DRT do not resemble those of the normal or the levodopa-naive state and may constitute the physiological substrate of the limitations and side effects of chronic DRT.
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On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms
TLDR
It is shown that signaling between the transmembrane guidance cue semaphorin 6A (Sema6A) and its receptor plexinA2 (PlexA2) regulates dendritic morphology of On but not Off SACs, thereby controlling direction-selective responses to visual stimuli.
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Basal ganglia oscillations and pathophysiology of movement disorders
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Local shuffling of spike trains boosts the accuracy of spike train spectral analysis.
TLDR
A compensation process that uses shuffling of interspike intervals (ISIs) for reliable identification of oscillations in the entire frequency range is proposed, providing a reliable estimation of auto- and cross-spectra of spike trains and making it an optimal tool for physiological studies of oscillatory neuronal phenomena.
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Visual Stimulation Reverses the Directional Preference of Direction-Selective Retinal Ganglion Cells
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Visual Stimulation Switches the Polarity of Excitatory Input to Starburst Amacrine Cells
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Inhomogeneous Encoding of the Visual Field in the Mouse Retina
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Low-Pass Filter Properties of Basal Ganglia–Cortical–Muscle Loops in the Normal and MPTP Primate Model of Parkinsonism
TLDR
The low-pass properties of the pathways connecting GP to MI to muscles suggest that parkinsonian tremor is not directly driven by the BG 5–10 Hz burst oscillations despite their similar frequencies.
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