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A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.
Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein
It is indicated that mpS2 is essential for normal differentiation of the antral and pyloric gastric mucosa and may function as a gastric-specific tumor suppressor gene.
Expression of Matrix Metalloproteinases during Rat Skin Wound Healing: Evidence that Membrane Type-1 Matrix Metalloproteinase Is a Stromal Activator of Pro-Gelatinase A
- A. Okada, C. Tomasetto, Y. Lutz, J. Bellocq, M. Rio, P. Basset
- BiologyThe Journal of cell biology
- 7 April 1997
Observations, together with the detection of high levels of the mature GelA form in the granulation tissue but not in the regenerating epidermis, suggest that MT1-MMP and GelA contribute to the restoration of connective tissue during rat skin wound healing.
STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER
The identification of proteins involved in inter-organellar interaction in the formation of MCSs involving late-endosomes including endogenous LE–ER MCS is reported.
Regulation of cell migration and survival by focal adhesion targeting of Lasp-1
It is found that stimulation of nonmotile and quiescent cells with growth factors or ECM proteins facilitates Lasp-1 relocalization from the cell periphery to the leading edge of the pseudopodium, where it associates with nascent focal complexes and areas of actin polymerization.
The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis
The present study observed that TFF1 triggers two types of cellular responses, and provides the first evidence of a dual antiproliferative and antiapoptotic role for TFF 1.
Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide.
A novel gene encoding the preproMTLRP protein, which presents similarity to motilin and is specifically expressed by enteroendocrine cells of the stomach and therefore represents a novel hormone.
Prediction of relapse and survival in breast cancer patients by pS2 protein status.
It is concluded that the pS2 status of human primary breast tumors is an important variable for the identification of patients at high risk for recurrence and death.
Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
The pS2 protein is similar in sequence to a porcine pancreatic protein that has been shown to inhibit gastrointestinal motility and gastric secretion and was specifically expressed and secreted by mucosa cells of the normal stomach antrum and body of both female and male individuals.
The Steroidogenic Acute Regulatory Protein Homolog MLN64, a Late Endosomal Cholesterol-binding Protein*
The results show that MLN64 plays a role at the surface of the late endosomes, where it might shuttle cholesterol from the limiting membrane to cytoplasmic acceptor(s).