Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS.
- R. Xu, Leimin Fan, M. Rieser, T. El-Shourbagy
- ChemistryJournal of Pharmaceutical and Biomedical Analysis
- 28 June 2007
Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata.
- M. Rieser, Z. Gu, X. Fang, L. Zeng, K. Wood, J. McLaughlin
- Chemistry, BiologyJournal of Natural Products
- 22 February 1996
Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds, three of which are among the first cis mono-tetrahydrofuran ring acetogenins to be reported.
Lack of a Clinically Significant Pharmacokinetic Interaction between Fenofibrate and Pravastatin in Healthy Volunteers
- W. Pan, L. Gustavson, B. Wallin
- Biology, MedicineJournal of clinical pharmacology
- 1 March 2000
The moderate increase in the formation of this pravastatin metabolite should not raise any clinical concerns due to its much lower pharmacological potency compared to pravASTatin and lack of toxicity.
Annonaceous acetogenins: An updated review
- X. Fang, M. Rieser, Z. Gu, Geng-Xian Zhao, J. McLaughlin
- Chemistry
- 1993
The Annonaceous acetogenins are an exciting new class of bioactive natural products whose antitumour, pesticidal and other bioactivities are due to inhibition of electron transport in mitochondria.…
Muricatetrocins A and B and Gigantetrocin B: Three New Cytotoxic Monotetrahydrofuran‐Ring Acetogenins from Annona muricata
- M. Rieser, X. Fang, Jon E. Anderson, L. R. Miesbauer, David L. Smith, J. McLaughlin
- Chemistry
- 3 November 1993
Extracts from the seeds of Annona muricata yielded three new Annonaceous acetogenins: muricatetrocin A (=…
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity
- T. V. von Geldern, H. Morton, D. Kempf
- Biology, MedicinePLoS Neglected Tropical Diseases
- 1 February 2019
A novel macrofilaricidal agent is identified, Tylosin A (TylA), which acts by targeting the worm-symbiont Wolbachia bacterium, and chemical modification of TylA leads to improvements in anti-Wolbachia activity and oral pharmacokinetic properties.
Bioactive single-ring acetogenins from seed extracts of Annona muricata.
- M. Rieser, X. Fang, J. K. Rupprecht, Y. Hui, D. Smith, J. McLaughlin
- BiologyPlanta Medica
- 1 February 1993
A new type of cytotoxic annonaceous acetogenin: Giganin from goniothalamus giganteus
- X. Fang, Rong Song, J. McLaughlin
- Chemistry, Biology
- 1 June 1993
Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384
ABT-384 has a wide potential therapeutic window for potential indications including Alzheimer’s disease and major depressive disorder and stable labeled substrates may be viable tools for measuring CNS effect during new drug development for other enzyme targets.
Determination of Absolute Configuration of Stereogenic Carbinol Centers in Annonaceous Acetogenins by 1H- and 19F-NMR Analysis of Mosher Ester Derivatives
The absolute configuration of the stereogenic carbinol centers in nine annonaceous acetogenins has been determined by careful 1 H- and 19 F-NMR analysis of (S)- and (R)-Mosher ester…
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