Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
The HTTLPR L(A)L( a) genotype exerts a moderate effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD.
Analysis of shared heritability in common disorders of the brain
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder.
- P. Arnold, T. Sicard, Eliza Burroughs, M. Richter, J. Kennedy
- Psychology, BiologyArchives of General Psychiatry
- 1 July 2006
Preliminary evidence that sequence variation in SLC1A1 is associated with susceptibility to OCD, particularly in males is provided, and support for the role of altered glutamatergic neurotransmission in the pathogenesis of OCD is provided.
Obsessive-compulsive disorder and the five-factor model of personality: distinction and overlap with major depressive disorder.
Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study
- P. Arnold, D. Rosenberg, E. Mundo, S. Tharmalingam, J. Kennedy, M. Richter
- Psychology, BiologyPsychopharmacology
- 9 April 2004
Evidence is provided that GRIN2B may be associated with susceptibility to OCD, and new and converging support for the role of altered glutamatergic neurotransmission in the pathogenesis of OCD is provided.
Comorbidity and pathophysiology of obsessive-compulsive disorder in schizophrenia: is there evidence for a schizo-obsessive subtype of schizophrenia?
- Alexandra Bottas, R. Cooke, M. Richter
- Psychology, MedicineJournal of Psychiatry & Neuroscience
- 1 May 2005
This review indicates that future studies should distinguish among apparent obsessive-compulsive symptoms (OCS) that occur only in the context of psychosis and that may overlap with psychotic phenomenology, representing a forme fruste of psychosis.
Quality of Life in OCD: Differential Impact of Obsessions, Compulsions, and Depression Comorbidity
- M. Masellis, N. Rector, M. Richter
- Psychology, MedicineCanadian journal of psychiatry. Revue canadienne…
- 1 March 2003
Obsession severity was found to significantly predict patient QOL, whereas the severity of compulsive rituals did not impact on QOL ratings, and treatments that directly target obsessions and secondary depression symptoms in OCD are warranted.
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
A meta-analysis of genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome revealed a meaningful structure within the eight disorders identifying three groups of inter-related disorders.
Symptom structure in obsessive-compulsive disorder: a confirmatory factor-analytic study.
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)
- Alexandra Bottas, M. Richter
- Medicine, PsychologyThe Pediatric Infectious Disease Journal
- 1 January 2002
The term “pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections” (PANDAS) has been applied to this subgroup of patients to indicate the hypothesized common etiopathogenesis of their symptoms.